Liquid chromatographic sampling passage cleaning device

Abstract

The invention provides a liquid chromatographic sampling passage cleaning device. The liquid chromatographic sampling passage cleaning device mainly comprises a microfluidic pump, a compressed air source, a capillary flow limiter, a liquid-gas switching valve, a sampling-cleaning switching valve, a waste liquid collecting cup, a waste liquid bottle, a sampling valve, a sampling port and a program controller. After sampling, a cleaning solution is used for reversely rinsing a liquid chromatographic sampling passage to reversely rinse particles left on a filter in the sampling process and discharge the particles out of a sampling pipeline first and then microflow gas is used for reversely purging the sampling passage to expel liquid left inside the pipeline so as to avoid sample dilution during sampling once again. The liquid chromatographic sampling passage cleaning device is suitable for various analytical-grade liquid chromatographs, comprising positive chromatography, reverse chromatography, ion chromatography and the like, as well as suitable for cleaning a sampling loop for flow injection analysis, so that cross pollution of samples is avoided, the sampling repeating precision is improved, and the service life of the sampling filter can be greatly prolonged.

Description

Technical field [0001] The invention relates to the field of liquid chromatographic instrument analysis, and belongs to an analytical instrument auxiliary device. Specifically, it is a cleaning device for the injection channel of a liquid chromatograph, which can avoid cross-contamination between samples during the analysis process of the liquid chromatograph. It also eliminates the dilution of new samples caused by residual liquid in the injection channel, which significantly improves the reliability and repeatability of the analysis. Background technique [0002] Liquid chromatograph is a widely used separation and detection instrument. It is often used for the analysis and detection of large quantities of samples in the laboratory. It plays an important role in many fields such as drug analysis, inspection and quarantine, and environmental monitoring. Due to the wide variety of samples analyzed and the large differences in properties, in order to avoid cross-contamination betw...

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Problems solved by technology

[0005] The common features of the above two methods are: 1. The cleaning solution enters the sampling channel in the same direction as the sample injection direction, so the particles on the sampling filter continue to accumulate, which easily leads to clogging and sample contamination; 2. The cleaning solution resides in the sampling channel. Therefore, when re-sampling, a small part of the cleaning solution will be mixed into the sample solution, dilute the sample solution, and affect the repeatability of the injection

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