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Albendazole-containing pharmaceutical composition against microsporidia for silkworms and its preparation and use method

A technology of albendazole and microsporidia, which is applied in the field of silkworm disease prevention and control, can solve the problems of cumbersome operation, high cost, and difficult acceptance by silkworm farmers

Active Publication Date: 2017-09-19
广西壮族自治区蚕业技术推广总站
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the cumbersome operation and high cost of spraying medicines in mulberry fields, silkworm farmers are difficult to accept, and Fangweiling has certain side effects on silkworm body development, cocoon quality and egg laying

Method used

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  • Albendazole-containing pharmaceutical composition against microsporidia for silkworms and its preparation and use method
  • Albendazole-containing pharmaceutical composition against microsporidia for silkworms and its preparation and use method
  • Albendazole-containing pharmaceutical composition against microsporidia for silkworms and its preparation and use method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Formula: 50.00% albendazole, 5% enrofloxacin, 12.00% starch, 15.00% microcrystalline cellulose, 15.00% polyvinylpyrrolidone and 2.50% sodium lauryl sulfate.

[0021] Preparation method: Weigh 500.00g albendazole, 50.00g enrofloxacin, 120.00g starch, 150.00g microcrystalline cellulose, 150.00g polyvinylpyrrolidone and 25.00g sodium lauryl sulfate, mix and stir evenly , to get 1.00kg drug compound powder.

Embodiment 2

[0023] Formula: 33.30% albendazole, 7.00% enrofloxacin, 33.30% starch, 12.40% microcrystalline cellulose, 12.40% polyvinylpyrrolidone and 1.60% sodium lauryl sulfate.

[0024] Preparation method: Weigh 333.0g albendazole, 70.00g enrofloxacin, 333.00g starch, 124.00g microcrystalline cellulose, 124.00g polyvinylpyrrolidone and 16.00g sodium lauryl sulfate, mix and stir evenly , to get 1.00kg drug compound powder.

Embodiment 3

[0026] Formula: 16.70% albendazole, 13.00% enrofloxacin, 52.45% starch, 8.50% microcrystalline cellulose, 8.50% polyvinylpyrrolidone and 0.85% sodium lauryl sulfate.

[0027] Preparation method: Weigh 167.00g albendazole, 13.00g enrofloxacin, 524.50g starch, 85.00g microcrystalline cellulose, 85.00g polyvinylpyrrolidone and 8.50g sodium lauryl sulfate, mix and stir evenly , to get 1.00kg drug compound powder.

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Abstract

The invention discloses a pharmaceutical composition containing albendazole for resisting microsporidia for silkworms. The pharmaceutical composition is a medicine compound powder prepared from albendazole, enrofloxacin, a filler and an appropriate compound cosolvent. The pharmaceutical composition disclosed by the invention can be applied to prevention and treatment of a pebrine disease and bacteriosis, and comprises two application modes: directly spraying the medicine compound powder on mulberry leaves to feed silkworms, or blending the medicine compound powder with water, preparing a solution, soaking the mulberry leaves and airing to feed the silkworms. The administration time is continuous 12-15 days until mounting and cocooning of silkworm from the fourth larva of silkworm; and the composition is fed once a day except for a moulting stage. The application method disclosed by the invention is convenient, simple and relatively practical. A result proves that a pebrine disease of the silkworms can be effectively prevented and treated.

Description

technical field [0001] The invention belongs to the technical field of silkworm disease prevention and control, and in particular relates to an albendazole-containing pharmaceutical composition against microsporidia for silkworms and a preparation and use method thereof. Background technique [0002] Bombyx mori microparticle disease is an infectious disease caused by Microsporidia infection. Microsporidia is listed as the only legal quarantine object for silkworm egg production in the world. According to quarantine data statistics, at present the country produces a generation of hybrids in silkworm eggs every year due to microspores 500,000 sheets are eliminated due to insect infection, the elimination rate is about 3.0%, and the direct economic loss is tens of millions of yuan. In order to control the infection of microsporidia in silkworm egg production, it is mainly used to fully disinfect the silkworm room, silkworm tools and surrounding environment to remove microspori...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K47/38A61K47/32A61K47/20A61P31/04A61P33/00A61K31/4184
CPCY02A50/30
Inventor 黄旭华潘志新祁广军黄深惠汤庆坤王霞韦廷秀朱方容林强唐亮
Owner 广西壮族自治区蚕业技术推广总站
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