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Magnetic nanoparticle magnetic resonance contrast agent and method for enhancing magnetic nanoparticle relaxivity

A magnetic nanoparticle and magnetic resonance contrast agent technology, which is applied in the fields of nanochemistry and biomedicine, can solve the problems of small size, weak magnetic moment, and decreased T2 imaging performance, and achieve simple operation, enhanced transverse relaxation rate, and high transverse The effect of relaxation rate

Active Publication Date: 2017-12-29
INST OF CHEM CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, due to its small size and weak magnetic moment, its T2 contrast performance will be greatly reduced

Method used

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  • Magnetic nanoparticle magnetic resonance contrast agent and method for enhancing magnetic nanoparticle relaxivity
  • Magnetic nanoparticle magnetic resonance contrast agent and method for enhancing magnetic nanoparticle relaxivity
  • Magnetic nanoparticle magnetic resonance contrast agent and method for enhancing magnetic nanoparticle relaxivity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] According to the literature (J.Am.Chem.Soc., 2004, 126, 273), Fe with an average particle size of 3.6 nm and a surface modified with oleic acid and oleylamine was first prepared. 3 o 4 Nanoparticles, its electron microscope photos and particle size statistics are attached figure 1 shown. Co-modify Fe with 20 mg oleic acid and oleylamine 3 o 4 Nanoparticles were dissolved in 4mL THF, and at the same time, 200 mg of polyethylene glycol 2000 (bisphosphate PEG2000, no conjugated structure in the molecule) was dissolved in 4 mL of THF, and Fe 3 o 4 The tetrahydrofuran solution and the tetrahydrofuran solution of bisphosphoric acid PEG2000 were mixed, and the ligand exchange reaction was heated at 60° C. for 8 h with stirring, and then cooled to room temperature. Add ether to precipitate, and the precipitate is magnetically separated and washed three times, and then dissolved in deionized water to obtain Fe with the surface modified by bisphosphonic acid PEG2000. 3 o 4...

Embodiment 2

[0069] According to the literature (J.Am.Chem.Soc., 2004, 126, 273), Fe with an average particle size of 3.6 nm and a surface modified with oleic acid and oleylamine was first prepared. 3 o 4 nanoparticles. Co-modify Fe with 20 mg oleic acid and oleylamine 3 o 4 Nanoparticles were dissolved in 4mL THF, and at the same time, 200mg of hydroxamic acid group-modified polyethylene glycol 2000 (hydroxamic acid PEG2000, containing p-π conjugated structure in the molecule) was dissolved in 4mL THF, and Fe 3 o 4 The tetrahydrofuran solution of hydroxamic acid PEG2000 and the tetrahydrofuran solution of hydroxamic acid PEG2000 were mixed, and the ligand exchange reaction was heated at 60° C. for 8 h with stirring, and then cooled to room temperature. Add diethyl ether to precipitate, the precipitate is magnetically separated and washed three times, and then dissolved in deionized water to obtain Fe with the surface modified by hydroxamic acid PEG2000 3 o 4 Nanoparticle magnetic re...

Embodiment 3

[0071] The 3.6nm Fe modified by bisphosphonate PEG2000 in Example 1 3 o 4 Nanoparticles and the 3.6nm Fe modified by hydroxamic acid PEG2000 in Example 2 3 o 4 Nanoparticles configured in a range of different concentrations of Fe 3 o 4 Nanoparticle solution, under the magnetic field strength of 3T, test its actual T2 MRI enhancement effect, and its T2 weighted image is as attached Figure 4 As shown, at the same Fe concentration, the hydroxamic acid PEG2000 modified Fe 3 o 4 Nanoparticles have higher contrast in T2-weighted images.

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Abstract

Magnetic nanoparticle magnetic resonance contrast agent and a method for enhancing the relaxation rate of magnetic nanoparticle, the invention belongs to the field of nanochemistry and biomedicine, in particular, it relates to modifying magnetic nanoparticle with a ligand having a conjugated structure at the end group to obtain high-performance magnetic nanoparticle Particulate magnetic resonance contrast agents. Using ligands with conjugated structures to modify magnetic nanoparticles can greatly enhance the transverse relaxation rate of magnetic resonance contrast agents of magnetic nanoparticles, and has broad application prospects.

Description

technical field [0001] The invention relates to the fields of nanochemistry and biomedicine, in particular to modifying magnetic nanoparticles with a ligand having a conjugated structure at the end group to obtain a high-performance magnetic nanoparticle magnetic resonance contrast agent. Background technique [0002] Due to their unique magnetic properties, magnetic nanoparticles have been widely studied and applied in the fields of magnetic resonance imaging, magnetic resonance detection, and biological separation, especially in the field of magnetic resonance imaging (MRI). Because MRI can provide good anatomical information, it is one of the most effective means of clinical diagnosis. It has unique advantages in the discovery and qualitative diagnosis of soft tissue lesions, especially in the diagnosis of tumors. So far, MRI has been able to safely and noninvasively obtain high-quality three-dimensional images with high spatial resolution. However, the low sensitivity o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/10
Inventor 高明远曾剑峰高振宇赵恩宇
Owner INST OF CHEM CHINESE ACAD OF SCI
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