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Compounded montmorillonite-saccharose ointment and preparation method and application thereof

A technology of compound montmorillonite and montmorillonite, which is applied in the field of medicine to achieve the effect of changing acidity and alkalinity, reducing exudation, and promoting ulcer healing

Active Publication Date: 2015-07-08
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the montmorillonite topical medicine specially used for the treatment of skin ulcers has not been reported yet.

Method used

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  • Compounded montmorillonite-saccharose ointment and preparation method and application thereof
  • Compounded montmorillonite-saccharose ointment and preparation method and application thereof
  • Compounded montmorillonite-saccharose ointment and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0149] Embodiment 1: the preparation of compound montmorillonite sucrose ointment

[0150] 1. The proportion of raw and auxiliary materials (w / w):

[0151]

[0152] 2. Prepared according to the following method:

[0153] (1) Take by weighing montmorillonite, sucrose, polyethylene glycol 6000, glycerin, sorbitol, sodium alginate by proportioning, spare;

[0154] (2) Put montmorillonite, sucrose, polyethylene glycol 6000, glycerin, sorbitol, sodium alginate, and sterile water into the dissolving tank, start stirring and heat up, continue to heat up to 135°C, sterilize, and keep at 60min; then cool down to 90°C and keep warm for later use;

[0155] (3) Pump the material obtained in step (2) into the shearing tank under aseptic conditions; at a temperature of 70°C, start the shearing machine at a low speed of 1800r / min for 5 minutes, and then shear at a high speed of 3000r / min Cut for 2 minutes; turn off the shearing machine, turn on the stirring, the rotating speed is 100r / ...

Embodiment 2

[0158] Embodiment 2: the preparation of compound montmorillonite sucrose ointment

[0159] 1. The proportion of raw and auxiliary materials (w / w):

[0160]

[0161] 2. Prepared according to the following method:

[0162] (1) Take by weighing montmorillonite, sucrose, polyethylene glycol 6000, glycerin, sorbitol, sodium alginate by proportioning, spare;

[0163] (2) Put montmorillonite, sucrose, polyethylene glycol 6000, glycerin, sorbitol, sodium alginate, and sterile water into the dissolving tank, start stirring and heat up, continue to heat up to 135°C, sterilize, and keep at 60min; then cool down to 80°C and keep warm for later use;

[0164] (3) The material obtained in step (2) is pumped into a shearing tank under aseptic conditions; at a temperature of 70°C, the shearer is turned on at a low speed of 2000r / min for 4 minutes, and then sheared at a high speed of 3200r / min. Cut for 2 minutes; turn off the shearing machine, start stirring at a speed of 100r / min, contin...

Embodiment 3

[0167] Embodiment 3: the preparation of compound montmorillonite sucrose ointment

[0168] 1. The proportion of raw and auxiliary materials (w / w):

[0169]

[0170] 2. Prepared according to the following method:

[0171] (1) Take by weighing montmorillonite, sucrose, polyethylene glycol 6000, glycerin, sorbitol, sodium alginate by proportioning, spare;

[0172] (2) Put montmorillonite, sucrose, polyethylene glycol 6000, glycerin, sorbitol, sodium alginate, and sterile water into the dissolving tank, start stirring and heat up, continue to heat up to 135°C, sterilize, and keep at 60min; then cool down to 85°C and keep warm for later use;

[0173] (3) The material obtained in step (2) is pumped into the shear tank under aseptic conditions; at a temperature of 70°C, the shearer is turned on at a low speed of 1900r / min for 4 minutes, and then sheared at a high speed of 3100r / min. Cut for 2 minutes; turn off the shearing machine, turn on the stirring, the rotating speed is 11...

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Abstract

The invention relates to compounded montmorillonite-saccharose ointment for treating skin ulcer and a preparation method and application thereof. The ointment is prepared from the following raw materials in parts by mass: 50-80 parts of montmorillonite, 410-656 parts of saccharose, 5-7 parts of polyethylene glycol 6000, 5-7 parts of glycerine, 10-16 parts of sorbitol, 5-7 parts of sodium alginate and 600-900 parts of sterile water. According to the ointment, montmorillonite and saccharose are adopted as pharmaceutic effective ingredients of the ointment disclosed by the invention, and montmorillonite, saccharose and pharmaceutic adjuvants are subjected to processes, such as moist-heat sterilization, dissolving, low-speed homogenizing, high-speed homogenizing, stirring, cooling and sterile filling, so as to prepare a medicinal preparation. The invention further provides application of the preparation in preparation of drugs for treating skin ulcer. Through skin external drug application, a relatively good effect on skin ulcers of different periods is achieved.

Description

technical field [0001] The invention relates to a pharmaceutical composition, a preparation method and application thereof, a compound montmorillonite sucrose ointment for treating skin ulcers, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Chronic skin ulcer is a high prevalence, high treatment cost, variable clinical situation, poor prognosis, and a pathological process seen in many diseases. different stage. With the increase in the number of people entering the elderly society and diabetes. Chronic skin ulcer has gradually become a common and frequently-occurring disease in clinical practice, increasing social and economic burdens, and clinical treatment is very difficult. [0003] Skin ulcers can be divided into trauma infection, pressure ulcers, venous ulcers, diabetic ulcers, etc. according to different pathogenic factors. In terms of the population, chronic refractory wounds on the body s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/06A61K9/06A61P17/02A61K31/7016
Inventor 乔敏陈立宗袁武杰刘钢李红新孟震晓
Owner SHANDONG SBOND PHARMA