Molluscicide LDS sustained-release granules and preparation method thereof

A technology of chlorinated salicylamine and slow-release granules, which is applied in the field of pesticides, can solve the problems of repeated application, powder scattering, powder easy to flow with the wind, etc., achieve sustained and slow release of drug effect, strong resistance to rain erosion , increase the effect of killing snails

Inactive Publication Date: 2015-07-29
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since chlorinated salicylamine is in a powder state, direct spraying can easily cause the powder to scatter and the drug will be consumed, and inhalation by the applicator will cause certain harm, especially in the environment where the oncomelania breeding ground is short of water, the powder can easily flow away with the wind, resulting in waste of the drug
In order to prevent problems such as powder pollution, the patent CN103583513 discloses a suspending agent

Method used

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  • Molluscicide LDS sustained-release granules and preparation method thereof
  • Molluscicide LDS sustained-release granules and preparation method thereof
  • Molluscicide LDS sustained-release granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0017] Example 1

[0018] Mix 50.0g of chlorinated salicylamine original medicine, 30.0g of soluble starch, 10g of dextrin, 8.5g of magnesium stearate, 0.6g of sodium lauryl sulfonate, and 0.9g of simethicone, and add appropriate amount of water. ,While heating to 60℃~70℃, stir evenly with the aid of a mixer, then extrude and granulate, dry and grind until the particles are finer than the pharmacopoeia sieve 10 mesh and 24 mesh, and the particle size is 10 mesh to 24 mesh Granules are chlorinated salicylamine sustained-release granules.

Example Embodiment

[0019] Example 2

[0020] Combine 50.0 g of chlorinated salicylamine original medicine, 30.0 g of amylose, 8.5 g of sodium carboxymethyl starch, 0.9 g of sodium cetyl trimethyl bromide, 0.6 g of polyoxypropylene polyoxyethylene glyceryl ether, hard Magnesium fatty acid 10.0g, mix well, add appropriate amount of water, stir and heat to 70℃, keep for 30 minutes, after it becomes viscous and moist mass, squeeze granulate, dry through pharmacopoeia sieve, take 10 mesh and 24 mesh The particles in between are chlorinated salicylamine sustained-release granules.

Example Embodiment

[0021] Example 3

[0022] Combine 40.0g of chlorinated salicylamine, 40.0g of amylose, 7.0g of diatomaceous earth, 10.0g of hydroxypropyl methylcellulose, 0.6g of cetyltrimethylammonium chloride, 1.5g of liquid paraffin, two Mix 0.9g methyl silicone oil evenly, add appropriate amount of water, and heat to 70~80℃, stir to make it into a viscous mass, extrude and granulate, dry, pass through a pharmacopoeia sieve, and take between 10 mesh and 24 mesh The particles are the chlorinated salicylamine sustained-release granules.

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Abstract

The invention belongs to the technical field of pesticides, and particularly relates to molluscicide LDS sustained-release granules. The molluscicide LDS sustained-release granules comprise LDS and auxiliary additives and comprise components in parts by weight as follows: 5-50 parts of the LDS and the balance of the auxiliary additives, wherein the auxiliary additives comprise 0.05-1 part of a surfactant, 0-10 parts of a binder, 0.2-1 part of an antifoaming agent, 0.2-10 parts of a lubricant and 30-90 parts of carriers. The LDS sustained-release granules are good in drug stability, are higher in adhesive force and rain wash resistance after scattered, have the characteristics of sustained and slow release and good effect and still have a better control effect after applied for 14 days, repeated usage is avoided, pollution is reduced, the usage cost is reduced, and the molluscicidal effect is improved.

Description

technical field [0001] The invention belongs to the technical field of pesticides, and in particular relates to a slow-release granule of molluscicide salicylamine chloride and a preparation method thereof. Background technique [0002] Schistosomiasis is a major infectious disease that seriously endangers the health of our people, and oncomelania is the only intermediate host of schistosomiasis. Eliminating oncomelania is an effective method to prevent and control schistosomiasis. The Chinese patent with publication number CN1958565A provides a new molluscicide quinone 4'-nitro-2', 5-dichlorosalicylanilide sodium (hereinafter referred to as chlorosalicylamine), which is Odorless and tasteless dark brown solid powder, soluble in methanol, ethanol, acetone, ethyl acetate, etc., slightly soluble in water, almost insoluble in ether, chemically stable at room temperature. Its chemical formula is C 13 h 7 N 2 Cl 2 o 4 Na, relative molecular mass M w =349.1, the structural ...

Claims

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Application Information

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IPC IPC(8): A01N37/42A01N25/12A01P9/00
Inventor 刘敏魏凤华覃杰元艺唐乾龚新国李桂玲徐兴建
Owner HUAZHONG UNIV OF SCI & TECH
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