Mussel adhesion and cell membrane antifouling double biomimetic multi-armed PEG and preparation method thereof

A kind of polymer and general formula technology, which is applied in paints containing biocide, antifouling/underwater coatings, coatings, etc., and can solve the problem of low coating density
CN104804195BActive Publication Date: 2018-01-23NORTHWEST UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NORTHWEST UNIV
Publication Date
2018-01-23

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Abstract

The invention discloses a bi-biomimetic modified multi-arm PEG represented by the general structural formula (I), in which catechol imitates mussel adhesion and zwitterionic imitates cell outer membrane structure and its preparation method. Through simple direct coating methods such as drop coating, spray coating, dip coating or spin coating, multi-arm polyethylene glycol flexible chains and zwitterionic imitation cell outer membrane structures are constructed on the surface of various substrates mediated by polydopamine. Double anti-biofouling surface. The biomimetic modified multi-arm PEG provided by the invention provides the possibility to prepare functional polymers containing a variety of functional groups with adjustable proportions due to its branched structure and multiple modifiable terminals; As a mediating layer, polydopamine can form a dense and stable dual anti-biofouling coating on the surface of almost any substrate even when the catechol content in multifunctional multi-arm PEG is limited.
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Description

technical field

[0001] The invention relates to a preparation method of mussel adhesion and cell membrane antifouling double bionic multi-arm PEG and its application to construct anti-biological pollution coatings on the surface of various substrates, belonging to the surface modification of biomedical polymer materials technology field. Background technique

[0002] In recent years, a series of problems such as thrombus, inflammation, and infection caused by biological pollutants such as proteins, cells, and bacteria have severely limited the clinical application of various biological materials. Therefore, it is imperative to effectively solve the problem of biological contamination on the surface of biological materials. important. At present, the commonly used simple and easy anti-biological contamination surface construction is mainly to modify the surface of existing biomedical materials, that is, to coat the surface of the base material with a coating with anti-foulin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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