Unlock instant, AI-driven research and patent intelligence for your innovation.

A method of promoting the release of carbon monoxide from a carbon monoxide releasing agent and preventing the formation of precipitates

A carbon monoxide and release agent technology, applied in the field of medicinal chemistry, can solve the problem of slow release rate of carbon monoxide, and achieve the effects of easy control of timing and rate, promotion of production, and rapid removal

Inactive Publication Date: 2017-12-26
JIAXING UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the release rate of carbon monoxide induced by amino acids and their derivatives or drug molecules is relatively slow, and a certain amount of precipitation will also be produced during the reaction.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A method of promoting the release of carbon monoxide from a carbon monoxide releasing agent and preventing the formation of precipitates
  • A method of promoting the release of carbon monoxide from a carbon monoxide releasing agent and preventing the formation of precipitates
  • A method of promoting the release of carbon monoxide from a carbon monoxide releasing agent and preventing the formation of precipitates

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Compound 1 (17mg, 34mmol) was added to 2.4mL DMSO, dissolved and then added to the reaction tube, added appropriate amount of amino acid or drug molecule aqueous solution (0.1mL, 1.035mol L -1 , [Compound 1]: [Amino acid or drug molecule] = 1:3) and 0.5 mL of aqueous solution, measuring infrared (Varian Scimitar 600) at regular intervals. The experimental process of adding EDTA to this system is similar to the above process, except that 0.1mL EDTA-2Na aqueous solution (3.45mol L -1 ), and the added aqueous solution is 0.4mL to ensure that the final solution is 3.0mL.

[0030] After adding proline or tiopronin to compound 1, the infrared spectrum changes significantly, such as figure 1 with 3 As shown, compound 1 is in 2068, 2031, 1989cm -1 There are three obvious carbonyl absorption peaks, these infrared characteristic peaks are obviously weakened after adding proline or tiopronin. It can be seen that after adding proline or tiopronin, the carbonyl group of compound 1 is gr...

Embodiment 2

[0033] Compound 2 (14mg, 34mmol) was added to 2.4mL DMSO, dissolved and then added to the reaction tube, and appropriate amount of drug molecule aqueous solution (0.1mL, 1.035mol L -1 , [Compound 1]: [Amino acid or drug molecule] = 1:3) and 0.5 mL of aqueous solution, measuring infrared (Varian Scimitar 600) at regular intervals. The experimental process of adding EDTA to this system is similar to the above process, except that 0.1mL EDTA-2Na aqueous solution (3.45mol L -1 ), and the added aqueous solution is 0.4mL, to ensure that the final solution is 3.0mL.

[0034] After compound 2 was added Tiopronin, the infrared spectrum changed significantly, such as Figure 5 As shown, compound 2 is in 2068, 2031, 1989cm -1 There are three obvious carbonyl absorption peaks, these infrared characteristic peaks are obviously weakened after the addition of tiopronin. This indicates that the characteristic peak of the carbonyl group of compound 2 gradually weakened after the addition of tiopro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for promoting a carbon monoxide releasing agent to release carbon monoxide and preventing the formation of precipitates, which belongs to the technical field of medicinal chemistry. The details of the method are as follows: the CO releasing agent is dissolved in dimethyl sulfoxide, and amino acids or derivatives thereof are added or drug molecules and EDTA in water. Adding EDTA can effectively promote the production of carbon monoxide, and can quickly remove the precipitate in the reaction. The method of the invention has good universality, the compounds involved in the reaction have good biocompatibility, the precipitate after releasing CO can be quickly and effectively removed, and the timing and rate of releasing carbon monoxide are easy to control.

Description

Technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to a method for promoting the release of carbon monoxide from a carbon monoxide release agent and preventing the formation of precipitation. technical background [0002] Carbon monoxide (CO) is a small biological molecule with biological activity in the human body. Like its analogue NO, CO plays a very important physiological and pathological role in the organism, such as relaxing blood vessels, inhibiting reperfusion injury, anti-apoptosis, anti-proliferation, anti-oxidation, antibacterial and so on. In order to explore the medicinal potential of this diatomic molecule, its precise on-site release will be a very critical issue. Transition metal carbonyl compounds are a large class of metal organic compounds that can cause the carbonyl (CO) to leave under appropriate conditions, such as light, substitution reaction, redox induction, etc. These properties of metal carbonyl ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/295A61K47/18A61P9/00A61P37/06A61P29/00
Inventor 刘小明姜秀娟陈丽梅张佳瑶龙莉
Owner JIAXING UNIV