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Polysaccharide mixture with skin whitening effect and method for manufacturing polysaccharide mixture

A mixture, the technology of Paeonia lactiflora polysaccharide, is applied to the polysaccharide mixture with whitening effect and the field of preparation thereof, can solve the problems of reduced purity of polysaccharide components, reduced whitening effect or free radical scavenging effect, low activity, etc., and achieves improved polysaccharide purity and activity The effect of enhancing, enhancing the effect

Inactive Publication Date: 2015-08-12
安徽中医药高等专科学校
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] It can be seen from the above description that there are also researches on Radix Paeoniae Alba, Angelica and Angelica dahurica in the prior art, but they mainly focus on the application of whole medicines, in the fields of health food, medicine and extraction technology, and there are also literature reports on some polysaccharide extracts of traditional Chinese medicine or their combinations. However, these traditional Chinese medicine polysaccharides have a large molecular weight range and are a mixture. It can be said that they are the total polysaccharides of a certain traditional Chinese medicine. The components that can play a whitening effect or free radical scavenging function are only a part of the total polysaccharides. The activity of other parts is too low or basically ineffective, so the total polysaccharides of traditional Chinese medicine contain active ingredients and inactive ingredients that have no effect at the same time, which greatly reduces the whitening effect or free radical scavenging effect, and the purity of the active polysaccharide components is also low. greatly reduced

Method used

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Effect test

preparation example Construction

[0014] The preparation method of the above-mentioned polysaccharide mixture with whitening effect comprises the following steps: mixing white peony polysaccharide, angelica polysaccharide, and angelica polysaccharide according to the above weight ratio, and grinding evenly to obtain the polysaccharide mixture with whitening effect.

[0015] In the above-mentioned preparation method of the polysaccharide mixture with whitening effect, the preparation method of the white peony polysaccharide comprises:

[0016] Take Radix Paeoniae Alba root and grind, add absolute ethanol and soak for 24 hours, the volume of described absolute ethanol and the weight ratio of Radix Paeoniae Alba root are 8:1; filter and discard the ethanol liquid, the obtained medicine dregs continue to add absolute ethanol to soak for 24 hours, described anhydrous ethanol The volume of ethanol and the root weight ratio of Radix Paeoniae Alba are 6:1; filter and discard the ethanol liquid, and evaporate the ethano...

Embodiment 1

[0031] The invention provides a preparation method of a polysaccharide mixture with whitening effect, comprising the following steps:

[0032] The preparation process of Radix Paeoniae Alba polysaccharides: take the dried roots of Radix Paeoniae Alba, crush them, take 80 mesh as the standard, add 8 times the amount of absolute ethanol (V / W), soak for 24 hours, filter, discard the ethanol liquid, and continue Add 6 times the amount of absolute ethanol (V / W), soak for 24 hours, filter, discard the ethanol liquid to obtain medicinal residues, place in the sun, ventilate and dry naturally, and evaporate to dry (volatile drying) ethanol. Transfer the dregs to a beaker, add 10 times the amount of distilled water, extract at 95°C for 2 hours, filter through double-layer gauze, keep the filtrate, add 8 times the amount of distilled water to the dregs, extract at 95°C for 2 hours, filter through double-layer gauze, Combine the filtrates in an Erlenmeyer flask, concentrate in a boiling ...

Embodiment 2

[0037] Take 50g, 50g, and 50g of white peony root, angelica, and angelica dahurica, respectively, and put them in 3 conical flasks, add 10 times the amount of absolute ethanol, soak for 24 hours, filter through double-layer gauze, discard the ethanol solution, and continue to add medicinal residues 8 times the amount of absolute ethanol, soaked for 24 hours, filtered through double-layer gauze, discarded the ethanol solution, placed the medicinal residues in a vacuum oven, and dried under reduced pressure at 60°C for 5 hours to obtain the medicinal residues of Radix Paeoniae Alba, Angelica, and Angelica dahurica respectively. Extract with 10 and 8 times the amount (500ml, 400ml) of distilled water at 95°C for 4 hours, and concentrate to 250ml in a water bath at 80°C.

[0038] Alcohol precipitation conditions: water extract of Radix Paeoniae Alba: slowly add absolute ethanol to the concentrated solution of Radix Paeoniae Alba so that the alcohol content reaches 35-45% (V / V), sti...

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Abstract

The invention relates to the technical field of cosmetics, in particular to a polysaccharide mixture with a skin whitening effect and a method for manufacturing the polysaccharide mixture. The polysaccharide mixture with the skin whitening effect comprises, by weight, 40-50 parts of radix paeoniae alba polysaccharides, 20-25 parts of angelica sinensis polysaccharides and 20-25 parts of angelica dahurica polysaccharides. The radix paeoniae alba polysaccharides, the angelica sinensis polysaccharides and the angelica dahurica polysaccharides are mixed with one another to obtain the polysaccharide mixture. The polysaccharide mixture and the method have the advantages that ethanol precipitation conditions are controlled, so that ineffective polysaccharide ingredients in the total polysaccharides of radix paeoniae alba, angelica sinensis and angelica dahurica can be abandoned, polysaccharide active portions, which are capable of obviously suppressing tyrosinase, suppressing generation of melanin and realizing the excellent skin whitening effect, in the total polysaccharides can be screened, the purity of functional polysaccharides of the active portions can be greatly improved, the purity of active polysaccharide ingredients with skin whitening and anti-oxidation effects can be improved, and the activity of the polysaccharide mixture can be enhanced; active polysaccharide components extracted from three traditional Chinese medicinal materials which are the radix paeoniae alba, the angelica sinensis and the angelica dahurica are mixed with one another according to certain proportions and are coordinated with one another, so that the excellent effects can be realized.

Description

technical field [0001] The invention relates to the technical field of cosmetics, in particular to a polysaccharide mixture with whitening effect and a preparation method thereof. Background technique [0002] Tyrosinase is the main limiting enzyme in the biosynthetic pathway of melanin. At present, whitening cosmetics mainly reduce the formation of melanin in the skin by inhibiting tyrosinase. To study the whitening effect, the tyrosinase inhibition test is generally used as the evaluation of the whitening effect, which is generally accepted by scholars. There are many kinds of whitening cosmetics on the market, but most of them contain chemical ingredients, which may have some adverse effects on the skin, and even have carcinogenic effects. Tyrosine inhibitors derived from natural medicines are green and safe, not only effective for pigmented skin diseases, but also of great significance in the formulation of whitening beauty cosmetics. [0003] In "Separation, Purificat...

Claims

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Application Information

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IPC IPC(8): C08L5/00
Inventor 秦亚东汪荣斌王存琴周娟娟钟正灵
Owner 安徽中医药高等专科学校
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