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A plateau sunscreen containing natural product echinacoside

A technology of echinacoside and sunscreen, which is applied in skin care preparations, cosmetics, cosmetic preparations, etc., can solve the problems of decreased skin comfort, achieve low skin irritation, good sunscreen effect, and anti-ultraviolet damage obvious effect

Inactive Publication Date: 2018-04-24
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chemical sunscreen substances are added to skin care products. Although the sunscreen factor of the product is improved, the effect of shielding the sun's ultraviolet rays is better, but the higher the sunscreen factor, the greater the amount of ultraviolet absorbers that need to be added, and the human skin will cause allergies. The greater the possibility, the greater the comfort of the skin

Method used

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  • A plateau sunscreen containing natural product echinacoside
  • A plateau sunscreen containing natural product echinacoside
  • A plateau sunscreen containing natural product echinacoside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A plateau sunscreen containing the natural product echinacoside, which consists of the following components (percentage by weight):

[0044] Oil phase:

[0045] Stearic Acid 10%

[0046] Glyceryl Monostearate 5%

[0047] Vaseline 4%

[0048]Nano Zinc Oxide 5%

[0049] Octyl Methoxycinnamate 3%

[0050] water box:

[0051] Triethanolamine 5%

[0052] Glycerin 6%

[0053] Azone 2%

[0054] Echinacoside 5%

[0055] Ethylparaben 0.1%

[0056] Vitamin C 0.4%

[0057] Fragrance 0.3%

[0058] Deionized water balance

[0059] The preparation method of the above-mentioned plateau sunscreen containing the natural product echinacoside is as follows:

[0060] (1) Stearic acid, glyceryl monostearate, vaseline, nano zinc oxide, octyl methoxycinnamate in the oil phase and triethanolamine, glycerin, azone, echinacoside, paraben in the water phase Ethyl ester, vitamin C, spices, and deionized water were heated to 80°C until they melted;

[0061] (2) Add the oil phase comp...

Embodiment 2

[0064] Example 2 Appearance inspection and content determination of the plateau sunscreen prepared in Example 1

[0065] Properties: This product is a white cream, fine and smooth, with suitable viscosity and slight fragrance.

[0066] Content determination:

[0067] 1. Reagents and instruments

[0068] Echinacoside reference substance (purchased from China Institute for the Control of Pharmaceutical and Biological Products)

[0069] BSA124S electronic analytical balance (Beijing Sartorius Instrument System Co., Ltd.); UV-visible spectrophotometer SPECORD-2000 (Germany Jena Instruments AG); microporous membrane 0.45µm (Beijing Mancang Technology Co., Ltd.)

[0070] 1.1 Preparation of echinacoside standard solution: Accurately weigh 0.02 g of echinacoside reference substance dried at 105°C to constant weight, put it in a 100 mL volumetric flask, add water to dissolve and dilute to the mark (200 µg / mL). Accurately weigh 25mL of the diluent, put it in a 100mL volumetric flask,...

Embodiment 3

[0077] Example 3 Study on the Pharmacological Activity of the Plateau Sunscreen Prepared in Example 1

[0078] The plateau sunscreen prepared in Example 1 and the anti-ultraviolet radiation ability of the natural product echinacoside contained in it are illustrated below through specific cell and animal experiments.

[0079] 1. Effect of echinacoside on HaCaT cell injury induced by UVB

[0080] 1.1 Cells: human immortalized epidermal cells (HaCaT) (Cell Resource Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, donated by the Department of Dermatology, Xijing Hospital, Fourth Military Medical University);

[0081] 1.2 Materials and instruments: 96-well culture plate (NUNC, Denmark), DMEM medium, 10% FBS (GIBCO, USA), tetramethylazolium salt (MTT), dimethylsulfoxide (DMSO), propidium iodide Pyridine (PI), trypsin (US Sigma Company), ultrapure water (US Millipore Company), PBS (Sigma Company);

[0082] LDH kit (Nanjing Jiancheng A0202), SOD kit ...

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Abstract

The invention provides a plateau sunscreen containing natural product echinacoside, the preparation method of which is as follows: oil phase components (stearic acid, glyceryl monostearate, vaseline, nano-zinc oxide, octylmethoxycinnamate Esters) and water phase components (triethanolamine, glycerin, azone, echinacoside, ethylparaben, vitamin C, deionized water) were heated to 80°C respectively, and the molten oil phase was added to the water phase, and the Stir, cool the paste to 40°C, stir well to degas, continue to stir slowly until it is completely emulsified to form a paste, and condense to obtain the plateau sunscreen containing echinacoside. The plateau sunscreen of the invention has a good protective effect on treating or preventing skin damage caused by high-intensity ultraviolet rays at plateaus.

Description

technical field [0001] The invention relates to a plateau sunscreen containing natural product echinacoside, which belongs to the field of cosmetics. Background technique [0002] Ultraviolet rays are electromagnetic waves with a wavelength of 200-400nm, among which ultraviolet rays with a wavelength of 200-290nm are called short-wave ultraviolet rays (UVC), ultraviolet rays with a wavelength of 290-320nm are called medium-wave ultraviolet rays (UVB), and ultraviolet rays with a wavelength of 320-400nm are called For long-wave ultraviolet (UVA). UVC has the greatest damage to human skin, but because most of the UVC radiated from the sun to the earth's surface is absorbed by the atmosphere and cannot reach the earth's surface, the effect of UVC on human skin can be ignored. Sunlight contains both UVA and UVB. The skin damage caused by ultraviolet rays is mainly related to UVA and UVB, and UVB is the main cause of skin damage. [0003] Plateau refers to the area above 3000m ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/67A61K8/60A61K8/27A61K8/37A61Q17/04
Inventor 王剑波张迪
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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