The invention discloses a formula of granules prepared from roots of three-nerved spicebush, dendrobium candidum and ginseng and a preparing technology of the formula. The granules prepared from roots of three-nerved spicebush, dendrobium candidum and ginseng are prepared from, by weight, 10-40 parts of roots of three-nerved spicebush, 10-40 parts of ginseng, 10-40 parts of dendrobium candidum, 4-10 parts of yam, 6-12 parts of radix astragali, 4-10 parts of fructus lycii, 8-14 parts of malt, 4-10 parts of radix rehmanniae, 4-10 parts of white peony roots, 4-10 parts of radix angelica sinensis and 2-8 parts of honey. The preparing technology of the formula of the granules prepared from roots of three-nerved spicebush, dendrobium candidum and ginseng comprises the steps that firstly, raw materials are screened; secondly, mixing is carried out, thirdly, smashing and grinding are carried out; fourthly, honey is heated; fifthly, stirring is carried out; sixthly, the finished product is prepared, wherein according to a certain proportion by weight part, the raw materials are mixed and smashed and pass through a 100-mesh screen, medicine powder is obtained and then processed in cooperation with honey to obtain a semiproduct, and then granulation is carried out. The granules can enhance the immunity and have an auxiliary protection function on chemical liver injury.