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A novel oral rehydration salt and its preparation method and use

A technology of rehydration salts and anhydrous glucose, which is applied in the fields of pharmaceutical formulas, medical preparations containing active ingredients, drug delivery, etc., and can solve the problems that it is difficult to have a broad-spectrum therapeutic effect, and the treatment of diarrhea needs to be further improved.

Active Publication Date: 2018-01-12
ANHUI HEALSTAR PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] As mentioned above, although some scholars have made some improvement research on oral rehydration salts, the effective rate of diarrhea treatment still needs to be further improved, the reason should be the diversity and complexity of the pathogenesis of diarrhea
Therefore, oral rehydration salts consisting only of basic ingredients are often difficult to have a broad-spectrum therapeutic effect

Method used

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  • A novel oral rehydration salt and its preparation method and use
  • A novel oral rehydration salt and its preparation method and use
  • A novel oral rehydration salt and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] S1: Weigh 72.5mmol sodium chloride, 1.5mmol sodium citrate, 8mmol hydroxymethylcellulose sodium, 11mmol potassium sodium tartrate, 3.5mmol potassium chloride, 0.5mmol zinc acetate, 1mmol zinc chloride, 90mmol anhydrous glucose;

[0043] S2: Add the sodium chloride, sodium hydroxymethylcellulose, sodium potassium tartrate, sodium citrate and 63 mmol anhydrous glucose weighed in step S1 into 900 ml of deionized water, stir and mix completely to obtain the initial preparation;

[0044] S3: adding potassium chloride, zinc acetate and zinc chloride weighed in step S1 to the initial preparation liquid, stirring and mixing completely to obtain a compound liquid;

[0045] S4: Add the remaining 27mmol of anhydrous glucose to the compound solution, stir evenly and completely, then use deionized water to make up to 1000ml, and finally filter through a 0.22μm filter element to obtain the oral rehydration salt of the present invention, Named BYY1.

Embodiment 2

[0047]S1: Weigh 75mmol of sodium chloride, 2mmol of sodium citrate, 8mmol of sodium hydroxymethylcellulose, 10mmol of potassium sodium tartrate, 2mmol of potassium chloride, 0.75mmol of zinc acetate, 1.5mmol of zinc chloride, and 95mmol of anhydrous glucose;

[0048] S2: Add the sodium chloride, sodium hydroxymethylcellulose, sodium potassium tartrate, sodium citrate and 76 mmol anhydrous glucose weighed in step S1 into 900 ml of deionized water, stir and mix completely to obtain the initial preparation;

[0049] S3: adding potassium chloride, zinc acetate and zinc chloride weighed in step S1 to the initial preparation liquid, stirring and mixing completely to obtain a compound liquid;

[0050] S4: Add the remaining 19mmol of anhydrous glucose to the compound solution, stir evenly and completely, then use deionized water to make up to 1000ml, and finally filter through a 0.22μm filter element to obtain the oral rehydration salt of the present invention, Named BYY2.

Embodiment 3

[0052] S1: Weigh 71mmol of sodium chloride, 2mmol of sodium citrate, 10mmol of sodium hydroxymethylcellulose, 12mmol of potassium sodium tartrate, 4mmol of potassium chloride, 0.75mmol of zinc acetate, 1.5mmol of zinc chloride, and 100mmol of anhydrous glucose;

[0053] S2: Add the sodium chloride, sodium hydroxymethylcellulose, sodium potassium tartrate, sodium citrate and 75 mmol anhydrous glucose weighed in step S1 into 900 ml of deionized water, stir and mix completely to obtain the initial preparation;

[0054] S3: adding potassium chloride, zinc acetate and zinc chloride weighed in step S1 to the initial preparation liquid, stirring and mixing completely to obtain a compound liquid;

[0055] S4: Add the remaining 25 mmol of anhydrous glucose to the compound solution, stir evenly and completely, then use deionized water to set the volume to 1000 ml, and finally filter through a 0.22 μm filter element to obtain the oral rehydration salt of the present invention, Named BYY3...

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Abstract

The invention relates to an oral rehydration salt, which comprises the following components: sodium chloride, sodium citrate, sodium hydroxymethylcellulose, potassium sodium tartrate, potassium chloride, zinc acetate, zinc chloride, Anhydrous dextrose and deionized water. The oral rehydration salt has excellent therapeutic properties through the selection of specific components, the content limitation of specific ions, and a specific preparation method, etc., and has an excellent cure rate of diarrhea, so it has a good reputation in the field of medicine. Application prospects and industrial production potential.

Description

technical field [0001] The invention relates to an oral liquid and its preparation method and use, more particularly to a novel oral rehydration salt and its preparation method and use, belonging to the field of drugs for treating diarrhea and dehydration. Background technique [0002] Diarrhea is a common disease in daily life, which refers to the frequency of defecation significantly exceeding the normal 2-3 times per day, or even more, showing thin stool, significant increase in water content, undigested food and / or mucus, etc. symptom. [0003] When diarrhea occurs or persists for a long time, patients will generally have anal discomfort and a sense of urgency to defecate, etc., which will seriously affect the life and work of the patient and cause a lot of inconvenience. [0004] In recent years, diarrhea has become a serious public health problem worldwide, especially in some underdeveloped countries. It has become the main cause of severe malnutrition and even death ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/30A61K9/08A61P3/12A61P1/12A61K33/14A61K31/7004A61K31/315
Inventor 陈嫣
Owner ANHUI HEALSTAR PHARM CO LTD
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