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Circulating tumor cell detection probe, preparation method and applied diagnostic sensor

A tumor cell and detection probe technology, applied in the field of medical detection, can solve the problems of low specificity and low sensitivity, and achieve the effects of high biocompatibility, improved capture efficiency, and improved sensitivity

Active Publication Date: 2019-02-01
JIANGHAN UNIVERSITY
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0005] The invention provides a circulating tumor cell detection probe and its preparation method and applied diagnostic sensor, which solves the technical problems of low sensitivity and low specificity in the diagnosis and detection of CTC cells in the prior art, and achieves the improvement of detection sensitivity and specificity. sexual effect

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  • Circulating tumor cell detection probe, preparation method and applied diagnostic sensor

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preparation example Construction

[0047] This embodiment also provides a preparation method for the above-mentioned circulating tumor cell detection probe, which includes the following three main steps, which are in accordance with the order of preparation:

[0048] Preparation of silicon nanoparticles;

[0049] Preparation of gold / silicon nanocomposites;

[0050] Preparation of enzyme label-gold / silicon nanoparticles-antibody complexes;

[0051] Wherein, the final product of the preparation step of silicon nanoparticle: silicon nanoparticle, is the raw material of the preparation step of gold / silicon nanocomposite material, the final product of the preparation step of gold / silicon nanocomposite material: gold / silicon nanocomposite material, is The raw material for the preparation step of the enzyme label-gold / silicon nano particle-antibody complex.

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Abstract

The invention belongs to the technical field of medical detection and discloses a circulating tumor cell (CTC) detecting probe, a preparation method thereof and an application diagnosis sensor. According to the invention, an efficient CTC detecting probe is formed through combination of antibody and an enzyme marker carrier, so that the capture rate of target cells is increased and the electrochemistry response signal is improved at the same time to realize high-sensitivity cell detection.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to a circulating tumor cell detection probe, a preparation method thereof and an applied diagnostic sensor. Background technique [0002] Malignant tumors are the number one factor threatening human life and health. At present, the annual incidence, death and prevalence of malignant tumors in my country rank among the highest in the world. Therefore, the diagnosis of cancer has become one of the most important links in safeguarding human health. Distant metastasis of tumor is the main cause of death in cancer patients. In the early stage of primary epithelial tumor formation and growth, some tumor cells with high vitality and high metastatic potential are separated from the tumor mother, enter the human peripheral blood circulation system to become circulating tumor cells (circulating tumor cells, CTC), and spread to distant places organ. A large number of studies have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/26
Inventor 张玮莹李娜曹一平
Owner JIANGHAN UNIVERSITY
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