Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New application of N-(1-benzylpiperidine-4-amidogen)-2-(4-phenoxy benzoyl) acetamide

A technology of benzoylphenoxy and benzylpiperidine, applied in the field of medicine

Inactive Publication Date: 2015-09-16
CHINA PHARM UNIV +1
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, there have been no reports on the use of this compound for the treatment of acute and chronic liver injury

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New application of N-(1-benzylpiperidine-4-amidogen)-2-(4-phenoxy benzoyl) acetamide
  • New application of N-(1-benzylpiperidine-4-amidogen)-2-(4-phenoxy benzoyl) acetamide
  • New application of N-(1-benzylpiperidine-4-amidogen)-2-(4-phenoxy benzoyl) acetamide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 N-(1-benzylpiperidin-4-yl)-2-(4-benzoylphenoxy)acetamide to CCl 4 Protective effect of induced acute liver injury in mice

[0024] 1. Test drugs

[0025] Drug dosage: N-(1-benzylpiperidin-4-yl)-2-(4-benzoylphenoxy)acetamide (BBA) high dose group is 0.5mg / kg, and the prepared concentration is 0.05mg / ml , administered by intragastric administration at 0.1ml / 10g; the middle dose group is 0.1mg / kg, the prepared concentration is 0.01mg / ml, administered by intragastric administration at 0.1ml / 10g; the low dose group is 0.02mg / kg, the prepared concentration is 0.002mg / ml, orally administered at 0.1ml / 10g.

[0026] Experimental control: normal saline (sodium chloride injection) was used for the blank control, administered by intragastric administration of 0.1ml / 10g; the positive control drug was bicyclol (Bicyclol, gifted by Professor Su Xianbin of Nanjing University of Technology), according to the clinical recommended dosage and Animal tolerance capacity, the de...

Embodiment 2

[0075] Example 2 Drugs for preventing and treating liver damage

[0076] The medicine is composed of N-(1-benzylpiperidine-4-amino)-2-(4-benzoylphenoxy)acetamide and a pharmaceutically acceptable carrier, and the dosage forms include tablets, capsules, Granules, pills, solutions, injections, sprays and aerosols.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the field of medicine, and particularly discloses application of N-(1-benzylpiperidine-4-amidogen)-2-(4-phenoxy benzoyl) acetamide (BBA) in preparation of medicine for preventing and curing lever injuries. Liver injuries comprise, but not limited to, chemical liver injuries, drug-induced liver injuries, viral hepatitis, alcoholic liver diseases, non-alcoholic fatty liver diseases and liver fibrosis and liver cirrhosis caused by the liver injuries and the liver diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to N-(1-benzylpiperidine-4-amino)-2-(4-benzoylphenoxy)acetamide (BBA) in the preparation and prevention of various acute and chronic New uses for liver injury drugs. Background technique [0002] Adiponectin receptors (Adiponectin Receptors, AdipoRs) are an important member of the progesterone and adiponectin Q receptor family. At present, two types, AdipoR1 and AdipoR2, have been found, and they are mainly distributed in skeletal muscle, liver, hypothalamus and It is also expressed on the cell surface of blood vessels and other organ tissues, in endothelial cells, pancreatic islet B cells, macrophages, monocytes and damaged vascular endothelial cells. AdipoRs is highly conserved in amino acid sequence and spatial structure, and its transmembrane domain is similar to G protein-coupled receptors (G Protein-Coupled Receptors, GPCRs), that is, it has seven transmembrane composed of α-helices ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4468A61P1/16A61P29/00
Inventor 叶波平万钰萌王颖薛晓文王璞罗清叶朝霞
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com