Preparing and application of probiotics-fermented traditional Chinese medicinal preparation for preventing and treating coccidiosis in chicken

A technology for chicken coccidiosis and traditional Chinese medicine preparations, which can be applied to medical preparations containing active ingredients, anti-infective drugs, drug combinations, etc., can solve problems such as unsatisfactory effects, achieve significant curative effects, promote reproduction, and improve therapeutic effects. Effect

Active Publication Date: 2015-09-23
山东宝来利来生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Over the years, researchers have also verified that some traditional Chinese medicines have the effect of killing and inhibiting chicken coccidiosis, but the effect is not satisfactory

Method used

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  • Preparing and application of probiotics-fermented traditional Chinese medicinal preparation for preventing and treating coccidiosis in chicken
  • Preparing and application of probiotics-fermented traditional Chinese medicinal preparation for preventing and treating coccidiosis in chicken
  • Preparing and application of probiotics-fermented traditional Chinese medicinal preparation for preventing and treating coccidiosis in chicken

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Preparation of probiotic fermented Chinese medicine preparation

[0054] 1 test material

[0055] 1.1 Experimental drugs The anti-coccidian Chinese herbal medicines Artemisia annua, Changshan, Verbena, Cortex Phellodendron, Sophora flavescens, Curcuma, Gardenia, Angelica, Tangerine Peel, Honeysuckle, Agrimony were all purchased from Jintailian University Pharmacy in Tai'an City, Shandong Province.

[0056] 1.2 Test strains of lactic acid bacteria: Lactobacillus rhamnosus 6133, Lactobacillus plantarum 7340, Lactobacillus rhamnosus 6-3, Lactobacillus plantarum LP, Pediococcus pentosaceae PP; Bacillus: Bacillus subtilis C1-0155, Bacillus subtilis C1-0090, Bacillus natto C1-0048, Bacillus subtilis C1-0050, Bacillus licheniformis C1-0309; the above-mentioned strains were all isolated from the Institute of Biology of Shandong Baolai Lilai Bioengineering Co., Ltd. The strain resource bank of Baolai Lilai Bioengineering Co., Ltd. can be isolated and prepared by conve...

Embodiment 2

[0109] Example 2 Test of probiotic fermented traditional Chinese medicine preparation for preventing and controlling coccidiosis of laying hens

[0110] 1 test material

[0111] 1.1 Test drugs

[0112] The traditional Chinese medicine ingredients fermented by probiotics: Artemisia annua, Changshan, Verbena, Cortex Phellodendri, Sophora flavescens, Curcuma, Gardenia, Angelica, Tangerine Peel, Honeysuckle, Agrimony were all purchased from Jintailian Pharmacy in Tai’an City, Shandong Province.

[0113] The ingredients of the pure Chinese medicine preparations: Artemisia annua, Changshan, Qinpi, Brucea javanica, Pulsatilla chinensis, Radix chinensis, Agrimony, and cinchona were all purchased from Jintailian Pharmacy in Tai'an City, Shandong Province.

[0114] Western medicine: diclazuril and sulfadiazine were purchased from the Veterinary Epidemic Prevention Station of Tai'an City, Shandong Province.

[0115] Strain: a lactic acid bacterium (Pediococcus pentosaceus, PP) - lactic...

Embodiment 3

[0172] Example 3 Probiotic Fermented Chinese Medicine Preparation Control Broiler Coccidiosis Test

[0173] 1 test material is the same as embodiment two

[0174] Only the mass parts of the components are different:

[0175] Chinese medicinal ingredients fermented with probiotics: 18 parts of Artemisia annua, 18 parts of Changshan, 12 parts of Verbena, 12 parts of Cortex Phellodendri, 10 parts of Sophora flavescens, 10 parts of Curcuma, 10 parts of Gardenia, 10 parts of Angelica, 8 parts of Chenpi, 8 parts of Honeysuckle parts, Agrimony 8 parts, decoction to extract its active ingredients, the concentration of the extract is 1.0 g·mL -1 . (The method is the same as Example 2.1, only the parts by mass are different, but similarly, the traditional Chinese medicine preparation of Example 3 can be prepared according to 2.1 parts by mass of Example 1).

[0176] The ingredients of pure Chinese medicine preparations: 5 parts of Artemisia annua, 6 parts of Changshan, 12 parts of Pu...

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Abstract

The invention discloses preparing and application of a probiotics-fermented traditional Chinese medicinal preparation for preventing and treating coccidiosis in a chicken. Traditional Chinese medicines comprise artemisia apiacea, antifebrile dichroa, herba verbenae, phellodendron, radix sophorae flavescentis, radix curcumae, cape jasmine, angelica sinensis, pericarpium citri reticulatae, honeysuckle and agrimonia pilosa. Effective traditional Chinese medicinal ingredients are extracted by three times of decoction; afterwards, a traditional Chinese medicinal culture medium substrate is prepared from the effective traditional Chinese medicinal ingredients; lactic acid bacteria PP (pediococcus pentosaceus) are inoculated in the traditional Chinese medicinal culture medium substrate; the inoculated traditional Chinese medicinal culture medium substrate is cultured to prepare the probiotics-fermented traditional Chinese medicinal preparation for preventing and treating the coccidiosis in the chicken. In comparison with the prior art, according to the preparing and the application of the probiotics-fermented traditional Chinese medicinal preparation for preventing and treating the coccidiosis in the chicken, a probiotics-fermented traditional Chinese medicinal aqueous extract is used as a target composition; not only are the further conversion and decomposition of a polysaccharide, starch, cellulose and pharmaceutical active ingredients in the traditional Chinese medicines promoted and are more effective active ingredients are generated, but also the activity of probiotics is improved; the growth and the release of the probiotics and metabolites thereof are facilitated; further, an anticoccidial treatment effect is obviously higher than that of a pure traditional Chinese medicinal preparation.

Description

technical field [0001] The invention relates to the preparation and application of a probiotic fermented traditional Chinese medicine preparation for preventing and treating chicken coccidiosis. Background technique [0002] Chicken coccidiosis is one of the main diseases that occur frequently, frequently, and are difficult to control in the current chicken industry. The disease is widely distributed and has a high infection rate. The most susceptible, coccidia exist almost everywhere where chickens are raised. According to statistics, its morbidity rate reaches 50%~70%, and once the onset mortality rate can be as high as 80%, and the growth and development of chickens that have been affected are stunted, and the egg production performance declines. The loss caused by chicken coccidiosis in the world can reach 80% every year. 100 million U.S. dollars, and the annual cost of anticoccidiostats in my country is as high as 600 million to 1.8 billion U.S. dollars. At present, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P33/02
Inventor 单宝龙陈雷谷巍秦波王红林显华王丽荣孙明杰崔斌王春凤
Owner 山东宝来利来生物工程股份有限公司
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