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Vascular wall elastic basement membrane and preparation method thereof

A blood vessel wall and elastic technology, applied in the field of new materials for bioengineering, can solve the problems of building the basement membrane of the blood vessel wall, and achieve the effects of convenient use, increased success rate, and low production cost

Inactive Publication Date: 2015-09-30
SUZHOU YOUJUN ENVIRONMENTAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The basement membrane is an important part of the blood vessel wall. The construction of the basement membrane is an important process in the vascular remodeling operation, but there is no good one in the prior art The method can effectively and safely build the basement membrane of the blood vessel wall

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] An elastic basement membrane of a blood vessel wall, which is mainly made of the following raw materials according to the ratio of parts by mass: 12 parts of collagen, 13 parts of hyaluronic acid, 12 parts of chitin, 10 parts of trehalose, 12 parts of silk fibroin, sericin 12 parts, 8 parts of proline, 9 parts of lysine, 12 parts of cellulose, 1 part of sodium carbonate, 25 parts of deionized water.

[0025] A preparation method for the elastic basement membrane of blood vessels, comprising the following steps:

[0026] (1) Dissolve sodium carbonate in deionized water to prepare a sodium carbonate solution with a mass concentration of 0.3%, and dissolve silk fibroin, sericin, proline and lysine in a mass ratio of 1:4:0.1:0.3 Stir and mix uniformly in the sodium carbonate solution to obtain the base liquid;

[0027] (2) Put chitin, cellulose and trehalose in a reaction kettle, make a melt at a temperature of 630°C and a pressure of 2.2MPa, dry and pulverize it into a po...

Embodiment 2

[0031] An elastic basement membrane of a blood vessel wall, which is mainly made of the following raw materials according to the ratio of parts by mass: 22 parts of collagen, 21 parts of hyaluronic acid, 25 parts of chitin, 18 parts of trehalose, 19 parts of silk fibroin, sericin 14 parts, 12 parts of proline, 17 parts of lysine, 32 parts of cellulose, 5 parts of sodium carbonate, 50 parts of deionized water.

[0032] A preparation method for the elastic basement membrane of blood vessels, comprising the following steps:

[0033] (1) Dissolve sodium carbonate in deionized water to prepare a sodium carbonate solution with a mass concentration of 1.2%, and dissolve silk fibroin, sericin, proline and lysine in a mass ratio of 2:5:0.3:0.5 Stir and mix uniformly in the sodium carbonate solution to obtain the base liquid;

[0034] (2) Put chitin, cellulose and trehalose in a reaction kettle, make a melt under the conditions of temperature 755°C and pressure 3.6MPa, and dry and pulv...

Embodiment 3

[0038] An elastic basement membrane of a blood vessel wall, mainly made of the following raw materials according to the ratio of parts by mass: 28 parts of collagen, 26 parts of hyaluronic acid, 30 parts of chitin, 22 parts of trehalose, 30 parts of silk fibroin, sericin 20 parts, 22 parts of proline, 24 parts of lysine, 35 parts of cellulose, 7 parts of sodium carbonate, 60 parts of deionized water.

[0039] A preparation method for the elastic basement membrane of blood vessels, comprising the following steps:

[0040] (1) Dissolve sodium carbonate in deionized water to prepare a sodium carbonate solution with a mass concentration of 1.9%, and dissolve silk fibroin, sericin, proline and lysine in a mass ratio of 3:7:0.5:0.7 Stir and mix uniformly in the sodium carbonate solution to obtain the base liquid;

[0041] (2) Put chitin, cellulose and trehalose in a reaction kettle, make a melt at a temperature of 820°C and a pressure of 4.1MPa, and then dry and pulverize it into a...

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Abstract

The invention discloses a vascular wall elastic basement membrane and a preparation method thereof. The vascular wall elastic basement membrane is prepared from the following raw materials in parts by mass: 12-28 parts of collagens, 13-26 parts of hyaluronic acid, 12-30 parts of chitin, 10-22 parts of trehalose, 12-30 parts of fibroin, 12-20 parts of sericin, 8-22 parts of proline, 9-24 parts of lysine, 12-35 parts of cellulose, 1-7 parts of sodium carbonate and 25-60 parts of deionized water. Compared with the prior art, the vascular wall elastic basement membrane disclosed by the invention has the following advantages that (1) the prepared vascular wall elastic basement membrane is capable of effectively remodelling a vascular wall and increasing the success rate of a vascular remodelling operation; and (2) the prepared vascular wall elastic basement membrane is safe and non-toxic, free from side effects, convenient to use, and low in production cost.

Description

technical field [0001] The invention relates to the field of new materials for bioengineering, in particular to a blood vessel wall elastic basement membrane and a preparation method thereof. Background technique [0002] With the development of society and the progress of science, the mutual embedding and infiltration among disciplines have been caused. Biomedical materials science, produced by the interpenetration and development of modern life sciences, materials science, medicine, engineering and other disciplines, has attracted more and more attention with the improvement of people's health and quality of life standards, and has become A hotspot of competing research and development. Biomedical materials, also known as biomaterials, refer to new inanimate high-tech materials that are used for medical purposes to diagnose, treat, repair or replace damaged tissues and organs or enhance their functions. Biomaterials include tissue engineering materials, nano-biomaterial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/20A61L27/24A61L27/22A61L27/02A61L27/50
Inventor 凌云金可心夏戊君凌天阳
Owner SUZHOU YOUJUN ENVIRONMENTAL SCI & TECH
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