A method for integrating microfluidic drive and metering

Abstract

The invention discloses a method for the integration of microfluidic driving and metering. Using the effect of ICEEF in microfluidic driving, the design of T-shaped channels is given, and based on the influence of microfluidic on strained manganese wire and polarizable platinum, The microfluidic driving part and the metering part are highly integrated to realize the effective driving and metering of the microfluid, and at the same time combine the peripheral feedback control circuit to automatically adjust the flow of the microfluid. The advantages of the present invention: (1) The application of ICEOF realizes the high-efficiency driving effect without valves in the microchannel; (2) The application concept of MEMS, the polarizable driving element and the strain sensing element of the metering part are embedded in the microchannel In the micro-channel, the integration of precise flow measurement and drive is realized; (3) the peripheral feedback circuit design realizes the controllable output of the micro-pump flow; (4) the semi-polarized Coating treatment can significantly enhance the driving effect, reduce the input of external voltage, and save energy and high efficiency.

Description

technical field [0001] The invention belongs to the field of bioengineering and relates to a method for integrating microfluidic drive and measurement. Background technique [0002] Since the early 1990s, the Swiss Academy of Sciences first proposed the concept of a micro-total analysis system based on micro-electromechanical systems (MEMS). After that, the analysis technology in the micro-channel of microfluidic chips has developed rapidly and has become one of the world's cutting-edge scientific and technological fields. one. The typical microfluidic driving part is only a few square centimeters. Microchannels with a width and depth of only tens to hundreds of microns are etched on the surface of glass, PDMS and other materials using micromachining technology, and external forces are applied to drive the microfluidic flow in the channel. Complete the injection operation. In recent years, with the gradual deepening of microfluidic research, the focus of microfluidic resea...

AI Technical Summary

Problems solved by technology

[0003] In the current microfluidic driving design, the most successful driving method is electroosmotic driving (EOF), but electroosmotic driving still has certain deficiencies. Strong electric field strength leads to the Joule heating effect, which affects the electric field and flow field; while the AC applied electric field that weakens the Joule heating effect will cause the average driving effect of the microfluid to be zero; the electric potential of the wall double layer in electroosmosis driving is generally less than 100mV, The transmission effect is not ideal

Images