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Anti-HIV JB protein rectum gel preparation and preparation method thereof

A gel preparation and protein technology, applied in the field of medicine, can solve the problems of safety, effectiveness and acceptability development failure, etc., achieve broad market prospects and application value, reasonable design, and convenient use

Active Publication Date: 2015-10-21
SHANXI JINBO BIO PHARMA CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the various new technologies, topical microbicides have attracted the most attention. Topical microbicides can prevent sexual partners from being infected with HIV even without using condoms. Unfortunately, the microbicides currently developed Development failures mostly due to safety, efficacy and acceptability issues

Method used

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  • Anti-HIV JB protein rectum gel preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] An anti-HIV virus JB protein rectal gel. The ingredients include mass concentrations of 1% JB protein, 2% carbomer, 0.5% propylene glycol, 15% glycerol, 0.5% hydroxyethyl cellulose, and 0.12% paraben. Gold methyl ester, 0.15% propyl paraben.

[0042] Taking the preparation of one kilogram of gel as an example, the carbomer concentration is 2%, that is, each kilogram of gel contains 20g of carbomer, the propylene glycol concentration is 0.5%, that is, each kilogram of gel contains 5g of propylene glycol and the glycerin concentration is 15%. , That is, each kilogram of gel contains 150g of glycerin, the concentration of hydroxyethyl cellulose is 0.5%, that is, each kilogram of gel contains 5g of hydroxyethyl cellulose, and the concentration of methyl paraben is 0.12%, that is, per kilogram of gel. It contains 12g of methyl paraben, and the concentration of propyl paraben is 0.15%, which means that each kilogram of gel contains 15g of propylparaben, and the mass concentratio...

Embodiment 2

[0045] An anti-HIV virus JB protein rectal gel. The ingredients include mass concentrations of 0.5% JB protein, 1.5% carbomer, 5% propylene glycol, 10% glycerol, 2% hydroxyethyl cellulose, and 0.1% paraben. Gold methyl ester, 0.5% propyl paraben.

[0046] Taking the preparation of one kilogram of gel as an example, the carbomer concentration is 1.5%, that is, each kilogram of gel contains 15g of carbomer, the propylene glycol concentration is 5%, that is, each kilogram of gel contains 50g of propylene glycol and the glycerin concentration is 10%. , That is, each kilogram of gel contains 100g of glycerol, the concentration of hydroxyethyl cellulose is 2%, that is, each kilogram of gel contains 20g of hydroxyethyl cellulose, and the concentration of methyl paraben is 0.1%, that is, per kilogram of gel. Contains 1g of methyl paraben and 0.5% of propylparaben, which means that each kilogram of gel contains 5g of propylparaben, and the mass concentration of JB protein is 0.5%, which m...

Embodiment 3

[0049] An anti-HIV virus JB protein rectal gel and its preparation method. The ingredients include mass concentrations of 3% JB protein, 0.7% carbomer, 8% propylene glycol, 12% glycerol, 3% hydroxyethyl cellulose, 0.15 % Methyl Paraben, 0.1% Propyl Paraben.

[0050] Taking the preparation of one kilogram of gel as an example, the carbomer concentration is 0.7%, which means that each kilogram of gel contains 7g of carbomer and the propylene glycol concentration is 8%, which means that each kilogram of gel contains 80g of propylene glycol and the glycerol concentration is 12%. , That is, each kilogram of gel contains 120g of glycerin, the concentration of hydroxyethyl cellulose is 3%, that is, each kilogram of gel contains 30g of hydroxyethyl cellulose, and the concentration of methyl paraben is 0.15%, that is, each kilogram of gel. It contains 1.5g of methyl paraben, and the concentration of propyl paraben is 0.1%, that is, 1g of propyl paraben per kilogram of gel, and the mass co...

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Abstract

The invention discloses an anti-HIV JB protein rectum gel preparation and a preparation method thereof. Potent microbicide JB protein is used as the main active ingredient of the rectum gel preparation which is mainly used for preventing AIDS pathophoresis. The optimized rectum gel preparation comprises, by mass concentration, 0.1-5% of JB protein, 0.1-10% of Carbomer, 0.5-10% of propylene glycol, 5-15% of glycerinum, 0.1-3% of hydroxyethyl cellulose, 0.1-1% of methylparaben and 0.1-1% of propylparaben and the balance water. The anti-HIV JB protein rectum gel preparation can be used for preventing AIDS pathophoresis and has the wide market prospect and high application value.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a gel product for preventing AIDS and a preparation method thereof. Background technique [0002] AIDS (Acquired immunodeficiency syndrome, AIDS) is an infectious disease caused by human immunodeficiency virus (Human immunodeficiency virus, HIV) infection and characterized by severe damage to the systemic immune system. Since its discovery, it has seriously threatened the survival of human beings. It has a huge impact on global population health and socioeconomic development. The main routes of HIV transmission are unsafe sexual contact, intravenous injection, blood transfusion, childbirth, and breastfeeding. Initially, HIV was only transmitted among drug addicts and homosexuals, but now sexual transmission, especially heterosexual sexual transmission, has become the main way of AIDS transmission. There is a gradually increasing trend. Since the first AIDS patient...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/32A61K38/17A61P31/18
Inventor 姜世勃陆路朱赟王茜杨霞兰小宾何振瑞王志强
Owner SHANXI JINBO BIO PHARMA CO LTD
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