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Application of aspergillus fumigates TEQA to preparation of oxazepam

A technology for fermentation and cultivation of Aspergillus fumigatus, applied in the application field of Aspergillus fumigatus TEQA in the preparation of oxazepam, which can solve the problems of residual by-products and influence on curative effect, and achieve the effects of short production cycle, low cost and simple operation

Active Publication Date: 2015-11-04
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Oxazepam is currently mainly produced by chemical synthesis. After it is made into tablets, there will be by-products remaining in the synthesis process, which will affect the curative effect.

Method used

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  • Application of aspergillus fumigates TEQA to preparation of oxazepam
  • Application of aspergillus fumigates TEQA to preparation of oxazepam
  • Application of aspergillus fumigates TEQA to preparation of oxazepam

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Embodiment 1

[0029] Embodiment 1, utilize Aspergillus fumigatus TEQA to prepare oxazepam

[0030] 1. Cultivation of Aspergillus fumigatus TEQA

[0031] The composition of the potato glucose liquid medium is: 200 g of peeled potatoes, 20 g of glucose, and add water to make the volume to 1000 mL. The preparation method of potato dextrose liquid medium: peel the potatoes and cut them into about 2cm 2 put into a beaker and boil for 30 minutes, then filter with double-layer gauze, take the filtrate and add glucose, then make up water, the pH is natural. Put 100ml of potato dextrose liquid medium in a 250ml Erlenmeyer flask, and sterilize it for later use.

[0032] A single colony of Aspergillus fumigatus TEQA was inoculated into 100ml potato dextrose liquid medium, and cultured with shaking at 28°C and 120r / min for 7 days.

[0033] 2. Preparation of crude extract

[0034] 1. Take the fermentation system obtained in step 1, use filter paper to separate and collect mycelia.

[0035] 2. Take ...

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Abstract

The invention discloses novel application of aspergillus fumigatus TEQA, and provides application of theaspergillus fumigatus TEQA to preparation of oxazepam. According to the invention, the application of the aspergillus fumigatus TEQA CGMCC NO. 3115 to preparation of the oxazepam is claimed. According to the invention, a method for preparing the oxazepam is also claimed. The method comprises thestep of performing fermental cultivation on the aspergillus fumigatus TEQA CGMCC NO. 3115 to obtain the oxazepam. The invention discloses the novel application of the aspergillus fumigatus TEQA. After fermental cultivation of the aspergillus fumigatus TEQA, the oxazepam can be obtained. The application is easy to operate, low in cost and short in production period, and has application potential on industrialization scale production. A novel way is provided for resource development of oxazepam medicines.

Description

technical field [0001] The invention relates to a new application of an existing bacterial strain, in particular to the application of Aspergillus fumigatus TEQA in the preparation of oxazepam. Background technique [0002] Oxazepam, whose physical form is white or off-white crystalline powder, is a short-acting benzodiazepine drug, a variety of benzodiazepines Metabolites of similar drugs (such as diazepam, temazepam, prazepam). Oxazepam was launched as a drug in Europe and America in the 1960s, and it is mainly used clinically for the treatment of anxiety, insomnia, and alcohol withdrawal. [0003] Oxazepam is currently mainly produced by chemical synthesis, and after it is made into tablets, there will be by-products remaining in the synthesis process, which will affect the curative effect. The use of microorganisms to produce oxazepam can obtain oxazepam monomers with high purity, thereby avoiding the residue of by-products of chemical synthesis, and the microorganism...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P17/10C12R1/68
Inventor 赵长琦梁子臻张璇李金杰
Owner BEIJING NORMAL UNIVERSITY