Lung cancer susceptibility gene noninvasive detection kit

Abstract

The present invention relates to a lung cancer susceptibility gene noninvasive detection kit which includes a mixture of a plurality of lung cancer susceptibility gene specific amplification primers, a sequencing primer and a PCR amplification reagent premix. The detection kit can simultaneously detect multiple areas of the lung cancer susceptibility gene, sequence information in the areas can be exactly obtained, according to the comprehensive information of each locus mutation by combination with susceptibility risk degree assessment method, lung cancer risk can be calculated, detection sensitivity is high, and further large number of samples can be simultaneously detected.

Description

technical field [0001] The invention belongs to the field of lung cancer susceptibility genes, in particular to a non-invasive detection kit for lung cancer susceptibility genes. Background technique [0002] Lung cancer is currently the leading cause of cancer death worldwide. In 2003, the death rate announced by the World Health Organization (WHO) was 1.1 million / year, and the incidence rate was 1.2 million / year. It mostly occurs in people over 40 years old, and the peak age of onset is between 60-79 years old. The prevalence rate of male to female is 2.3:1. The risk factors of lung cancer mainly include smoking, air pollution, ionizing radiation and genetic factors. [0003] The so-called disease susceptibility refers to the predisposition to suffer from a certain disease or a certain type of disease determined by genetics. People with disease susceptibility must have specific genetic characteristics, simply put, they have a susceptibility genotype for a certain disea...

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Problems solved by technology

[0004] At present, there are many research results on the detection of a single susceptibility gene for lung cancer, but the specific gene loci in different studies have different correlations with lung cancer susceptibility, and individual loci cannot yet accurately evaluate the susceptibility of lung cancer

[0005] CN200610116093.X discloses a kit for detecting lung cancer susceptibility through PARP1 gene, CYP1A1 gene and XRCC1 gene, but the detection of three genes cannot fully and accurately evaluate the susceptibility of lung cancer

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