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Application of hydroxy-aluminum montmorillonite in preparation of antacid

A technology of hydroxyaluminum montmorillonite and antacid, applied in the fields of aluminum/calcium/magnesium active ingredients, digestive system, drug combination, etc.

Active Publication Date: 2015-11-18
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are no reports on the research on hydroxyaluminum montmorillonite at home and abroad, especially the research on using hydroxyaluminum montmorillonite as an antacid

Method used

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  • Application of hydroxy-aluminum montmorillonite in preparation of antacid
  • Application of hydroxy-aluminum montmorillonite in preparation of antacid
  • Application of hydroxy-aluminum montmorillonite in preparation of antacid

Examples

Experimental program
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Effect test

preparation example Construction

[0016] The application of the hydroxyaluminum montmorillonite of the present invention in the preparation of antacids, the preparation method of the antacids, the steps are as follows:

[0017] (1) Soak the montmorillonite clay in purified water for 1-2 hours under stirring, and then use a sand mill or colloid mill for liquid crushing to obtain a suspension; let it stand for 6-8 hours; remove the sedimentation liquid, and mix the upper layer The suspension was centrifuged in a decanter centrifuge, and the collected relative density was 2.0-2.2g / cm 3 After passing through a 120-160 mesh sieve, the feed liquid is acidified with a hydrochloric acid solution with a concentration of 1-3N, and the temperature of the acidification process is controlled at a temperature of 10-70°C; stir for 1-3 hours until the pH of the liquid is 1.5-3.5 Then separate with a centrifuge, and the filter cake is repeatedly washed with purified water until the pH value is neutral after washing; then, the ...

experiment example 1

[0038] Experimental example 1: Experimental research on the influence of time and concentration of montmorillonite in hydrochloric acid solution

[0039] Raw materials: montmorillonite, hydrochloric acid;

[0040] Add 5 pieces of 80mL 3N hydrochloric acid solution into the Erlenmeyer flask, cover it and place it in a shaker, keep the temperature at 70±2°C, and then add 1.0g of pure montmorillonite sample respectively. The capped bottle stopper was shaken at a constant temperature of 120r / min for a certain period of time (0h, 3h, 12h, 24h, 36h), and after taking it out, it was centrifuged with a desktop centrifuge (maximum speed 6000r / min), and the supernatant was taken and spectrophotometrically Determination of the concentration of aluminum ions in the dissolution solution and calculation of AL 2 o 3 Dissolution rate. AL 2 o 3 Dissolution rate of Al 2 o 3 The ratio of dissolved mass to initial mass. The residue after centrifugation was repeatedly washed with distilled...

experiment example 2

[0051] Experimental example 2: Activation experiment of montmorillonite in hydrochloric acid solution

[0052] Raw materials: montmorillonite, hydrochloric acid;

[0053] Weigh 5g of ground montmorillonite sample and pour it into a 250ml Erlenmeyer flask; add 200ml of hydrochloric acid (concentrations are 1.0N, 1.5N and 3.0N respectively), bathe in water at 70±2°C for 3h; filter and wash repeatedly with deionized water to pH ≈6, 1O0 ℃ drying after standby, XRD and SEM analysis of the sample after acid treatment.

[0054] (1) XRD analysis

[0055] The above montmorillonite treated with hydrochloric acid is consistent with the XRD patterns of montmorillonite activated without hydrochloric acid and with different concentrations of 1.0N, 1.5N, 3.0N hydrochloric acid;

[0056] Montmorillonite has a higher degree of crystallization and fewer active sites that can react with hydrochloric acid. After activation by hydrochloric acid, the activity was significantly improved, indicati...

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Abstract

The invention discloses application of hydroxy-aluminum montmorillonite in preparation of an antacid. The medicinal effective component of the antacid is hydroxy-aluminum montmorillonite; the mass percentage of the hydroxy-aluminum montmorillonite in the medicament is 50 to 100 percent, and the balance is pharmaceutic adjuvants; the hydroxy-aluminum montmorillonite is prepared by the following steps of soaking or eluting montmorillonite with an acid solution and separating the montmorillonite; then soaking or eluting the montmorillonite with a sodium hydroxide solution; modifying the montmorillonite by using aluminum hydroxide gel, separating hydroxy montmorillonite, and activating the hydroxy montmorillonite at high temperature to prepare the hydroxy-aluminum montmorillonite. According to the application disclosed by the invention, the medicament is administrated through a gastrointestinal tract, so that the effective component can be used for neutralizing a pH value of gastric juice of a patient and further reducing the activity of pepsase, so that the actions of alleviating gastralgia and promoting gastric ulcer healing can be realized; the hydroxy-aluminum montmorillonite is discharged outside through a digestive tract, so that the aim of resisting gastric acid is achieved.

Description

technical field [0001] The present invention relates to the use of hydroxyaluminum montmorillonite, and further relates to the use of said hydroxyaluminum montmorillonite in the preparation of antacids for treating conditions or diseases associated with harmful gastric acid levels. Background technique [0002] The human stomach secretes substances such as gastric acid and pepsin to help it digest food. However, these substances (we call them attack factors) can also damage the mucosa in the stomach and intestines and cause ulcers, that is, erosion of the gastrointestinal mucosa. Complications such as perforation and bleeding may also occur. Normally, the stomach and intestines are well equipped to protect themselves from gastric acid and pepsin. This balance is very important to maintain a healthy digestive system, but this balance is easily broken, either due to excessive gastric acid secretion, or due to weakened gastric mucosal protective function, gastric acid invades ...

Claims

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Application Information

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IPC IPC(8): A61K33/06A61P1/04
Inventor 乔敏袁靖尧袁武杰袁洲杰
Owner SHANDONG SBOND PHARMA
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