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Sweet potato extract as well as preparation method and application thereof

The technology of extract and sweet potato is applied in the field of sweet potato extract and preparation thereof, and achieves the effects of low production cost, strong proliferation inhibition ability and simple operation.

Active Publication Date: 2015-11-25
INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, studies on sweet potato anticancer extracts have not been reported

Method used

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  • Sweet potato extract as well as preparation method and application thereof
  • Sweet potato extract as well as preparation method and application thereof
  • Sweet potato extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: the preparation of sweet potato flour

[0059] Wash, drain and slice 1000g of fresh sweet potatoes, put them in a tray and pre-freeze them in a -40°C refrigerator for 24 hours, then take them out and put them in a vacuum freeze dryer, and dry them at -66°C for 48 hours at a vacuum degree of 50Pa Finally, adopt universal pulverizer to pulverize, make the sweet potato flour of 80-100 purpose.

Embodiment 2

[0060] Embodiment 2: the preparation of sweet potato flour

[0061] Wash, drain, and slice 1500g fresh sweet potatoes, put them in a tray and pre-freeze them in a refrigerator at -20°C for 36 hours, take them out and put them in a vacuum freeze dryer, and dry them at -70°C for 48 hours at a vacuum of 100Pa , using a universal pulverizer to pulverize to obtain 80-100 mesh sweet potato flour.

Embodiment 3

[0062] Embodiment 3: the preparation of sweet potato crude extract

[0063] Get 100 g of sweet potato powder obtained in Example 1, add 3 times the volume (300 mL) of chloroform and methanol mixture (2:1, v / v), extract at -4 ° C for 24 hours, filter after extraction, and collect Add 3 times the volume (300mL) of chloroform and methanol mixture to the supernatant and residue, extract at -4°C for 2 hours, repeat the extraction twice, combine the supernatants, and store them at a temperature of 35°C and a vacuum of Under the condition of 0.09MPa, the organic reagent (chloroform and methanol) was removed by rotary evaporation at 70rpm to obtain 2g crude sweet potato extract.

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Abstract

The invention discloses a sweet potato extract as well as a preparation method and application thereof. The preparation method of the sweet potato extract comprises the following steps: 1) cleaning, draining, slicing and drying sweet potatoes, and grinding the sweet potatoes so as to obtain sweet potato powder; 2) extracting the sweet potato powder by taking a mixed solution of chloroform and methanol as an extracting agent; 3) dissolving a coarse sweet potato extract in the mixed solution of chloroform and methanol; then implementing solid-phase extraction and separation on an obtained coarse sweet potato extract solution by taking chloroform and acetone as eluents, and collecting an acetone elution component; and 4) implementing adsorption chromatography on the acetone elution component by virtue of a chromatographic column which uses macroporous adsorption resin as an adsorbent, sequentially eluting the elution component through water as well as ethanol solutions which are 20-40%, 50-60% and 70-80% in volume percentage, and collecting an elution component of the ethanol solution which is 70-80% in volume percentage so as to obtain the sweet potato extract. Pharmacodynamic tests show that the sweet potato extract has a relatively strong proliferation inhibiting capacity on colon cancer cells, breast cancer cells and the like.

Description

technical field [0001] The invention relates to a sweet potato extract and its preparation method and application. Background technique [0002] At present, cancer is one of the major diseases that cause human death. According to the latest data released by the World Health Organization, the global incidence of cancer of 80-100 orders is expected to rise sharply from 14 million in 2012 to 22 million in 2032. During the same period, the number of cancer deaths will also rise from 8.2 million per year to 13 million per year. In 2012, the incidence of cancer in my country accounted for almost half of the world, ranking first. Traditional cancer treatments, such as radiotherapy and chemotherapy, are effective in killing cancer cells to a certain extent, but they can also damage and destroy normal cells. Compared with traditional cancer treatments, the advantages of natural anticancer active ingredients are high activity and no or low adverse reactions. [0003] Sweet potato (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/39A61P35/00
Inventor 木泰华赵仕婷张苗孙红男陈井旺
Owner INST OF AGRO FOOD SCI & TECH CHINESE ACADEMY OF AGRI SCI
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