Method for preparing hemostatic clips through surface-passivated degradable magnesium alloy

A magnesium alloy, hemostatic clip technology, applied in wound clips, metal material coating processes, etc., to achieve the effect of ensuring effectiveness, improving blood biocompatibility, and reducing degradation rate

Inactive Publication Date: 2015-11-25
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But the present invention prepares the magnesium alloy material of hemostatic c

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  • Method for preparing hemostatic clips through surface-passivated degradable magnesium alloy
  • Method for preparing hemostatic clips through surface-passivated degradable magnesium alloy

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Example Embodiment

[0018] Example 1:

[0019] A method for preparing a hemostatic clip using a degradable magnesium alloy with a surface passivation. The degradable magnesium alloy material is composed of Mg, Zn, Zr, and Sr, and the mass percentage of each component is: Zn is 3%, Zr is 0.8%, Sr is 0.3%, Mg is the balance, the preparation steps are as follows:

[0020] 1) Add 99.99wt% Mg, analytically pure Zn, Mg-Zr master alloy and Mg-Sr master alloy to the graphite crucible, wherein the mass percentage of Zr in the Mg-Zr master alloy is 30%, and Mg-Sr The mass percentage of Sr in the composition of the master alloy is 30%, evacuated to 1×10 -2 Pa, pass argon protection, heat to 780°C and keep it warm for 20 minutes, then fully stir at 8r / s for 10 minutes and then start to cool down. After the temperature drops to 650°C, pour into the crystallizer to obtain a 60mm diameter ingot;

[0021] 2) Put the above round ingot in an air furnace, heat it at 350℃ for 6h for homogenization annealing, then heat it ...

Example Embodiment

[0027] Example 2:

[0028] A method for preparing a hemostatic clip using a degradable magnesium alloy with a passivation surface. The degradable magnesium alloy material is composed of Mg, Zn, Zr, Ca and Ag, and the mass percentage of each component is: Zn is 3%, Zr It is 0.7%, Ca is 0.3%, Ag is 0.3%, and Mg is the balance. The preparation steps are as follows:

[0029] 1) Add 99.99wt% Mg, analytically pure Zn, Mg-Zr master alloy, Mg-Ca master alloy and Mg-Ag master alloy to the graphite crucible, where the mass percentage of Zr in the Mg-Zr master alloy is 30%, the mass percentage of Ca in the Mg-Ca master alloy composition is 30%, the mass percentage of Ag in the Mg-Ag master alloy is 30%, and vacuum to 1×10 -2 Pa, pass argon protection, heat to 780°C and keep it warm for 20 minutes, then fully stir at 8r / s for 10 minutes and then start to cool down. After the temperature drops to 650°C, pour into the crystallizer to obtain a 60mm diameter ingot;

[0030] 2) Put the above ingot i...

Example Embodiment

[0035] Example 3:

[0036] A method for preparing a hemostatic clip using a degradable magnesium alloy with a surface passivation. The degradable magnesium alloy material is composed of Mg, Zn, Zr, and Ca, and the mass percentage of each component is: Zn is 3%, Zr is 0.6 %, Ca is 0.3%, Mg is the balance, the preparation steps are as follows:

[0037] 1) Add 99.99wt% Mg, analytically pure Zn, Mg-Zr master alloy, and Mg-Ca master alloy to the graphite crucible, wherein the mass percentage of Zr in the Mg-Zr master alloy is 30%, and Mg-Ca The mass percentage of Ca in the composition of the master alloy is 30%, evacuated to 1×10 -2 Pa, pass argon protection, heat to 780°C and keep it warm for 20 minutes, then fully stir at 8r / s for 10 minutes and then start to cool down. After the temperature drops to 650°C, pour into the crystallizer to obtain a 60mm diameter ingot;

[0038] 2) Put the above-mentioned round ingot in an air furnace, keep it at 300℃ for 36h for homogenization annealing, ...

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Abstract

Disclosed is a method for preparing hemostatic clips through surface-passivated degradable magnesium alloy. The magnesium alloy is composed of alloy elements including, by mass, 3% of Zn, 0.5-1.0% of Zr, 0.0-1.0% of Sr, 0.0-1.0% of Ca, 0.0-1.0% of Ag and the balance Mg. The preparation method includes the steps that ingots obtained through casting are squeezed into profile materials at the temperature of 250-400 DEG C, machined into the hemostatic clips, then subjected to aging treatment and finally subjected to surface passivating treatment. The method for preparing the hemostatic clips through the surface-passivated degradable magnesium alloy has the advantages that the hemostatic clips prepared through the method have proper obdurability and can meet the requirements for mechanical properties of materials by a broken end of a closed vessel; the degrading speed of the hemostatic clips made of the surface-passivated magnesium alloy is controllable, it is guaranteed that the hemostatic clips keep effective within two weeks in clinical use and can be completely corroded and degraded 1-2 months later after performing function.

Description

Technical field [0001] The invention relates to the preparation of a vascular hemostatic clip for laparoscopic surgery, in particular to a method for preparing a hemostatic clip using a degradable magnesium alloy whose surface is passivated. Background technique [0002] Hemostatic clip is a medical device mainly used in laparoscopic surgery to seal and open blood vessels. Because of its good sealing effect and convenient application, it is widely used in minimally invasive surgery. Clinically, there are mainly metal clips and polymer clips. Among them, metal hemostatic clips are mainly silver clips, tantalum clips and titanium clips. In the early stage of laparoscopic surgery, silver hemostatic clips are generally used. But its long-term retention in the human body will produce greater toxicity, and it has been rarely used at present. In recent years, the most widely used titanium alloy hemostatic clip in clinical practice, the main manufacturer is Johnson & Johnson. There a...

Claims

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Application Information

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IPC IPC(8): C22C1/03C22C23/04C22F1/06C23C22/34A61B17/122
Inventor 陈民芳李桢刘德宝由臣
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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