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A plug-in for capillary electrophoresis and electrochromatography

A capillary electrophoresis and electrochromatography technology, applied in the field of analytical chemistry instruments and equipment, can solve the problems of inferior capillary electrophoresis separation and analysis technology, inconvenient use, high price, etc., and achieve diversified operation modes, convenient installation, and reduced instrument costs. Effect

Active Publication Date: 2018-03-09
李绍平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to its own limitations, commercial capillary electrophoresis instruments, such as when used in conjunction with mass spectrometers, often need to connect another pressure pump to introduce the sheath fluid, which is inconvenient to use, and commercial capillary electrophoresis instruments are expensive, resulting in capillary electrophoresis separation and analysis techniques. Far less popular than HPLC separation and analysis technology

Method used

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  • A plug-in for capillary electrophoresis and electrochromatography
  • A plug-in for capillary electrophoresis and electrochromatography
  • A plug-in for capillary electrophoresis and electrochromatography

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Such as figure 1 As described above, a capillary electrophoresis and electrochromatography plug-in 100 is used to connect to a liquid chromatograph 200, including a liquid inlet unit, a high-voltage power supply 1, a first high-pressure liquid storage tank 3a fixed with a first electrode 2a, and a second high-pressure liquid storage tank 3a fixed with a second electrode 2a. The second high-voltage liquid storage tank 3b and the liquid outlet unit of the electrode 2b; one pole of the high-voltage power supply 1 is electrically connected to the first electrode 2a through a wire 9a, and the other pole of the high-voltage power supply 1 is electrically connected to the second electrode 2b through a wire 9b , the first electrode 2a is inserted and fixed in the first high-pressure liquid storage tank 3a, the second electrode 2b is inserted and fixed in the second high-pressure liquid storage tank 3b, and both the first electrode 2a and the second electrode 2b are platinum elec...

Embodiment 2

[0037] Embodiment 1 is roughly the same as Embodiment 2, and its difference is only, as Figure 4 As shown, the capillary electrophoresis and electrochromatography plug-in 100' only needs a first high-pressure liquid storage tank 3a with a first electrode 2a fixed therein. Here, one end of the high-voltage power supply 1 is electrically connected to the electrode 2a through a wire 9a, and the other end is electrically connected to the electrode 2a through a wire. 9b is directly grounded, and one end of the capillary or capillary electrochromatographic column 30 communicates with the electrospray needle 51 on the mass spectrometer, and the third liquid inlet pipe 8c is also directly connected to the interface of the electrospray needle 51, and the liquid outlet unit also includes The first three-way connector 16a arranged on the first liquid inlet pipe 8a and the second regulating pipe 7b connected to one port of the first three-way connector 16a, the second regulating pipe 7b i...

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Abstract

The invention relates to the technical field of analytical chemistry instruments and equipment, in particular to a plug-in for capillary electrophoresis and electrochromatography, including a high-voltage power supply, two high-pressure liquid storage tanks with electrodes fixed thereon, and a high-pressure liquid storage tank, capillary tube or electrochromatographic column. The liquid inlet unit for liquid supply; the liquid inlet unit can be connected to the liquid chromatograph, one pole of the high-voltage power supply is electrically connected to one of the electrodes, and the other pole of the high-voltage power supply is electrically connected to the other electrode or directly grounded, capillary or electrochromatographic The column can be connected between two high-pressure liquid storage tanks or between one of the high-pressure liquid storage tanks and the mass spectrometer; the invention is easy to install and can be directly used in various liquid chromatography instruments or the combination of liquid chromatography instrument and mass spectrometer. In the capillary electrophoresis separation analysis, the sample injector, degassing device and high-pressure pump of the liquid chromatography are directly used to complete the capillary electrophoresis, without a separate capillary electrophoresis instrument, which reduces the cost of the analytical instrument.

Description

technical field [0001] The invention relates to the technical field of analytical chemistry instruments and equipment, in particular to a capillary electrophoresis and electrochromatography plug-in that can be connected to a liquid chromatograph. Background technique [0002] Capillary electrophoresis, also known as high-efficiency capillary electrophoresis, is a liquid phase separation technology with capillary as the separation channel and high-voltage direct current electric field as the driving force; and with the introduction of the stationary phase of liquid chromatography into capillary electrophoresis, the development of electrochromatography Technology, which combines the separation mechanism of electrophoresis and liquid chromatography, further expands the application range of capillary electrophoresis. Capillary electrophoresis has many operating modes, easy to develop analysis methods, and the separation and analysis results are impressive, especially for charged...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/447G01N30/02
Inventor 李绍平葛利丫赵静
Owner 李绍平