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Microsphere capsules with assistant protection function on gastric mucosal lesion and preparation method thereof

A technology for gastric mucosal injury and protective function, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, capsule delivery, etc. Poor timeliness of effect and other issues, to achieve high bioavailability and the effect of protecting gastric mucosa

Active Publication Date: 2015-12-02
QINGDAO CHENLAND MARINE BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, most of the health care products on the domestic market with the effect of protecting gastric mucosa are traditional Chinese medicine compound prescriptions, and the product preparation technology is backward.

Method used

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  • Microsphere capsules with assistant protection function on gastric mucosal lesion and preparation method thereof
  • Microsphere capsules with assistant protection function on gastric mucosal lesion and preparation method thereof
  • Microsphere capsules with assistant protection function on gastric mucosal lesion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A microsphere capsule with an auxiliary protective function against gastric mucosal injury, comprising a capsule shell and contents, wherein the contents are composed of the following components according to the weight ratio:

[0028] Chitosan: Codonopsis pilosula extract: Atractylodes macrocephala extract: Panax notoginseng extract=20:38:30:12.

[0029] The specific steps of the preparation method of the content are as follows:

[0030] (1) Under stirring condition, dissolve 50g chitosan in 20L 1% (v / v) acetic acid solution; Then, dilute chitosan solution with distilled water, make its final concentration be 2mg / ml; Use 1M sodium hydroxide solution Regulate the pH value of chitosan solution to be 6;

[0031] (2) Slowly add Codonopsis pilosula extract, Atractylodes macrocephala extract and Panax notoginseng extract to the chitosan solution in sequence, the ultrasonic power is 450W, the working time is 20s, the intermittent time is 15s, and the working time is 90 times ...

Embodiment 2

[0035] A microsphere capsule with an auxiliary protective function against gastric mucosal injury, comprising a capsule shell and contents, wherein the contents are composed of the following components according to the weight ratio:

[0036] Chitosan: Codonopsis pilosula extract: Atractylodes macrocephala extract: Panax notoginseng extract=30:32:28:10.

[0037] The specific steps of the preparation method of the content are as follows:

[0038] (1) Under stirring condition, dissolve 80g chitosan in 32L 1% (v / v) acetic acid solution; Then, dilute chitosan solution with distilled water, make its final concentration be 2mg / ml; Use 1M sodium hydroxide solution Regulate the pH value of chitosan solution to be 6;

[0039] (2) Slowly add Codonopsis pilosula extract, Atractylodes macrocephala extract and Panax notoginseng extract to chitosan solution in sequence, ultrasonic power is 500W, working time is 20s, intermittent time is 15s, working 90 times, and embedding suspension is obt...

Embodiment 3

[0043] A microsphere capsule with an auxiliary protective function against gastric mucosal injury, comprising a capsule shell and contents, wherein the contents are composed of the following components according to the weight ratio:

[0044] Chitosan: Codonopsis pilosula extract: Atractylodes macrocephala extract: Panax notoginseng extract=40:28:24:8.

[0045] The specific steps of the preparation method of the content are as follows:

[0046] (1) Under stirring condition, dissolve 100g chitosan in 40L 1% (v / v) acetic acid solution; Then, dilute chitosan solution with distilled water, make its final concentration be 2mg / ml; Use 1M sodium hydroxide solution Regulate the pH value of chitosan solution to be 6;

[0047] (2) Slowly add Codonopsis pilosula extract, Atractylodes macrocephala extract and Panax notoginseng extract to chitosan solution in sequence, ultrasonic power is 550W, working time is 20s, intermittent time is 15s, working 90 times, and embedding suspension is obt...

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Abstract

The invention relates to microsphere capsules with an assistant protection function on gastric mucosal lesion. The microsphere capsules are prepared from, by weight, 20-40 parts of chitosan, 25-55 parts of pilose asiabell root extract, 20-50 parts of langehead atractylodes rhizome extract and 8-12 parts of radix notoginseng extract. The microsphere capsules with the assistant protection function on the gastric mucosal lesion have the advantages that the chitosan is taken as a carrier to be combined with the traditional Chinese medicines, and the chitosan and pilose asiabell root extract, langehead atractylodes rhizome extract and radix notoginseng extrac mutually cooperate for compatibility to achieve the effect of protecting the gastric mucosa; meanwhile, microspheres with the particle size about 10-150 micrometers are prepared by adopting an ultrasonic emulsion technology, absorption is good, and the bioavailability is high.

Description

technical field [0001] The invention relates to the technical field of health care products and preparation methods thereof, in particular to a microsphere capsule capable of auxiliary protection against gastric mucosal damage and a preparation method thereof. Background technique [0002] Gastric mucosal injury belongs to peptic ulcer, which is a common and frequently-occurring disease worldwide. Its etiology and pathogenesis have not been studied clearly, and it is generally considered to be the result of an imbalance between attacking factors and defensive factors in the digestive tract. In recent years, experimental studies on the protective effect of traditional Chinese medicine on the gastric mucosa have shown that it mainly inhibits the secretion of gastric acid and pepsin, strengthens the gastric mucosa-mucus barrier, improves the blood circulation of the gastric mucosa, inhibits the killing of Helicobacter pylori, and induces the endogenous protective factors of the ...

Claims

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Application Information

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IPC IPC(8): A61K36/344A61K47/36A61K9/16A61K9/48A61P1/04
Inventor 李丽杰王尚龙李八方邹圣灿
Owner QINGDAO CHENLAND MARINE BIOTECH CO LTD
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