A method for manufacturing a 384-hole solid-phase synthesis reaction device for nucleic acid synthesis
A solid-phase synthesis and reaction device technology, applied in metal processing and other fields, can solve the problems of unsatisfactory daily use and high price, and achieve the effects of outstanding device performance, improved wear resistance and non-variability, and reduced costs
Active Publication Date: 2016-09-14
通用生物(安徽)股份有限公司
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Problems solved by technology
[0003] Among the existing 768-channel nucleic acid synthesis equipment, the original factory provides a disposable 384 reaction device, which is expensive and cannot meet daily use
Method used
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Embodiment Construction
[0027] Embodiments of the present invention will be described in detail below.
[0028] Such as figure 1 Shown, a kind of manufacturing method of the 384 hole solid-phase synthesis reaction device that is used for nucleic acid synthesis comprises the following steps:
[0029] 1.1 Mapping of the reaction chamber of the synthesizer
[0030] Accurately map the reaction chamber of the 768-channel nucleic acid synthesizer, with a height accuracy of ±0.1mm and a length and width accuracy of ±0.01mm;
[0031] 1.2 Positioning
[0032] Precisely locate the reagent outlet position of the 768-channel nucleic acid synthesizer, and locate the layout of the reaction wells on the platform of the device according to the mapping results in step 1.1;
[0033] 1.3 Fine car
[0034] According to the surveying and mapping data in step 1.1, the hard peek plate with the substrate grade of 150CA30 is finished according to the actual requirements, and the finish turning process requires a height t...
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The invention discloses a manufacturing method for a 384 hole solid-phase synthesis reaction device used for nucleic acid synthesis. A manufactured 384 hole solid-phase synthesis reaction device can be used repeatedly, and cost is reduced. The method comprises steps: 1, synthesizer reaction chamber surveying and mapping: accurately surveying and mapping a 768 channel nucleic acid synthesizer reaction chamber; 2, positioning: accurately positioning a reagent outlet position of the 768 channel nucleic acid synthesizer reaction chamber; 3, finish turning: according to surveying and mapping data, performing finish turning processing on a hard peek panel as actual need; 4, and marking: respectively imprinting 1, 2, 3, and the like, 22, 23, 24, A, B, C, and the like, N, O, P on the periphery of the X-axis and the Y-axis of the 384 hole solid-phase synthesis reaction device, as hole positioning identifications. A product manufactured by the method is high in precision, low in device investment, and low in cost, and the device can be used repeatedly.
Description
technical field [0001] The invention relates to the field of nucleic acid synthesis instruments, in particular to a method for manufacturing a 384-hole solid-phase synthesis reaction device for nucleic acid synthesis. Background technique [0002] Globally, biotechnology and industry are showing a trend of accelerated development. As an important part of the fourth industrial revolution, major developed countries and emerging economies have made deployments for the development of bioindustry. The application of high-throughput, fully automatic, and low-cost biosynthesis equipment is becoming more and more important. [0003] Among the existing 768-channel nucleic acid synthesis equipment, the original factory provides a disposable 384 reaction device, which is expensive and cannot meet daily use. Contents of the invention [0004] The technical problem to be solved in the present invention is to provide a method for manufacturing a 384-hole solid-phase synthesis reaction ...
Claims
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IPC IPC(8): B26D9/00
Inventor 刘宗文雍金贵武新春
Owner 通用生物(安徽)股份有限公司