Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of preparation method of chlorpromazine hydrochloride multicapsule sustained-release granule

A technology of chlorpromazine hydrochloride and sustained-release granules, which is applied in the directions of non-active ingredient medical preparations, capsule delivery, microcapsules, etc., can solve the problems of disintegrating drugs, high utilization rate, burst release, etc., and achieves convenient preparation, The effect of low cost and simple operation

Active Publication Date: 2018-05-08
嘉兴天源药业有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The utilization rate of chlorpromazine through injection treatment is high, but high-frequency injection treatment brings a lot of inconvenience. Therefore, degradable polymer materials can be used to encapsulate chlorpromazine to make drug sustained-release microspheres, but ordinary drug-loaded microspheres are in After a period of degradation in the body, disintegration will occur, resulting in burst release of the drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of chlorpromazine hydrochloride multicapsule sustained-release granule
  • A kind of preparation method of chlorpromazine hydrochloride multicapsule sustained-release granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1: a kind of preparation method of chlorpromazine hydrochloride multicapsule sustained-release granule, it comprises the following steps:

[0026] S1. Preparation of the first solution: Sodium hydroxide is added to the phosphate buffer solution in which chlorpromazine hydrochloride is dissolved, and the content of sodium hydroxide in the initial solution is 0.5%; an initial solution is formed, and the copolymer is poured into the initial solution In, the first solution is formed; wherein, the copolymer is a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer with a polyoxyethylene content of 69%, and the content of the copolymer in the first solution is 65% %; The content of chlorpromazine hydrochloride in the phosphate buffer saline solution that is dissolved with chlorpromazine hydrochloride is 0.8%;

[0027] S2. Preparation of the second solution: dissolving the biodegradable polymer material in an organic solvent to form a second solution;...

Embodiment 2

[0032] Embodiment 2: a kind of preparation method of chlorpromazine hydrochloride multicapsule sustained-release granule, it comprises the following steps:

[0033] S1. The preparation of the first solution: add in the phosphate buffer saline solution that is dissolved with chlorpromazine hydrochloride, and the content of potassium hydroxide in the initial solution is 3%; Form initial solution, copolymer is poured in the initial solution, forms The first solution; wherein, the copolymer is a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer with a polyoxyethylene content of 73%, and the content of the copolymer in the first solution is 75%; The content of chlorpromazine hydrochloride in the phosphate buffer that is dissolved with chlorpromazine hydrochloride is 2.7%;

[0034] S2. Preparation of the second solution: dissolving the biodegradable polymer material in an organic solvent to form a second solution; wherein, the biodegradable polymer material is a po...

Embodiment 3

[0039] Embodiment 3: a kind of preparation method of chlorpromazine hydrochloride multicapsule sustained-release granule, it may further comprise the steps:

[0040] S1. Preparation of the first solution: Add alkali to the phosphate buffer solution that is dissolved with chlorpromazine hydrochloride to form an initial solution, and pour the copolymer into the initial solution to form the first solution; wherein, the copolymer is poly Oxyethylene content is 70% polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer, and the content of copolymer in the first solution is 68%; The alkali is sodium hydroxide and potassium hydroxide, weight Ratio is 1:2, and the content of alkali in initial solution is 1%; The content of chlorpromazine hydrochloride is 1.2% in the described phosphate buffered saline solution that is dissolved with chlorpromazine hydrochloride;

[0041] S2. Preparation of the second solution: dissolving the biodegradable polymer material in an organic so...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of chlorpromazine hydrochloride multicapsule sustained-release granules, which comprises the following steps: S1. preparation of the first solution; S2. preparation of the second solution; S3. preparation of the third solution; S4. Preparation of the final solution; S5. Stirring and pumping; S6. Freeze-drying. The present invention uses the degradable macromolecule material to carry chlorpromazine to make drug slow-release granules, so that the drug can be wrapped in the slow-release granules to form multi-vesicle-structured granules with uniform particle size and gentle drug release. After degrading for a period of time, disintegration will not occur to cause drug burst release. The method of the invention is simple in operation, convenient in preparation, low in cost and suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical technology and polymer technology, and in particular relates to a preparation method of chlorpromazine hydrochloride multicapsule sustained-release granules. Background technique [0002] At present, the number of mental patients in the world is constantly increasing. According to the prediction of the World Health Organization, by 2020, mental illness will become one of the five major diseases that make people lose their ability to work, and will seriously affect the development of the world. [0003] According to the data provided by the Mental Health Center of the Chinese Center for Disease Control and Prevention in early 2009, the number of patients with various mental disorders in my country is more than 100 million. At present, there are as many as 16 million severe mental patients in the country, and reports about mental patients harming or being injured have appeared frequently. In recent yea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/50A61K47/32A61K47/34A61K47/10A61K31/5415A61P25/18
Inventor 朱雪标姜晓磊许少辉刘明秋
Owner 嘉兴天源药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com