33 results about "Chlorpromazine Hydrochloride" patented technology

The invention belongs to the technical field of chemical products, and relates to a method for improving the fermentation yield of long-chain dicarboxylic acid. According to the method, the long-chain dicarboxylic acid is produced by a microbiological fermentation method by taking C10 to C18 n-alkanes as raw materials; the method is characterized in that alpha oxidative decarboxylation inhibitor and beta-oxidation inhibitor are added in a fermentation production process to reduce the alpha-oxidative decarboxylation and beta-oxidation capacities of strains, wherein the alpha oxidative decarboxylation inhibitor is one or mixture of more of chlorpromazine hydrochloride, phenobarbital sodium, crylic acid and polyacrylic acid, and the concentration is 0.01 to 1mmol / L; and the beta-oxidation inhibitor is one or mixture of more of mercaptoacetic acid, sodium thioglycollate, ranolazine, ranolazine dihydrochloride and mildronate, and the concentration is 0.01 to 1 mmol / L. Compared with the prior art, the method has the advantages of high acid producing speed, weak alpha oxidative decarboxylation and beta-oxidation capacity, low unit consumption of alkane, and high fermentation alkane conversion rate, and is particularly suitable for preparing the long-chain dicarboxylic acid.

The invention discloses a preparation method of a supermolecule globular micelle based on an antidepressant medicament chlorpromazine. The method comprises the following steps: constructing a medicament carrier through the supermolecule interaction of amphiphilic sulfonated calix [4] arene and an antidepressant medicament chlorpromazine hydrochloride, dissolving the amphiphilic sulfonated calix [4] arene and the antidepressant medicament chlorpromazine hydrochloride in water, and uniformly mixing to obtain a nano supermolecule globular micelle solution; and non-covalently modifying a targeting agent trimethyl chitosan through a bonding site of the calix arene on the surface of the micelle to obtain the supermolecule micelle loaded with trimethyl chitosan on the surface. The preparation method has the advantages that the preparation method is simple and convenient, and fewer subjective and objective raw materials are used; the medicament load rate is high since the medicament molecules are the constructing units of the medicament carrier and the medicament molecules are immobilized; the micelle can be used for non-covalently modifying the targeting agent trimethyl chitosan through the bonding site of the surface calix arene so that the micelle has a wide application prospect in the field of targeted medicament delivery.

The invention discloses a percutaneous give drug system, which comprises: a drug storeroom, the gel drug layer comprises drug, solvent, transdermal accelerating agent and gelatinizing agent; one adsorption layer comprised solvent absorption material of solvent in absorbable drug storeroom; one isolating layer between drug storeroom and adsorption layer, which is of non-woven fabrics or semipermeable membrane to make solvent of gas or liquid pass through successfully; adsorption layer can joint isolating layer of drug storeroom in opposite directions of closing up to skin of drug storeroom. The percutaneous give drug system in this invention can increase drug level in drug storeroom of the system to elevate drug transdermal speed, as well as increase controlled release effect of percutaneous give drug and absolute bioavailability, enhance drug curative effect, decrease drug waste, and depress preparation cost of the system. The invention is fit particular to percutaneous give drug system for water-soluble drug of propranolol hydrochloride, verapamil hydrochloride and chlorpromazine hydrochloride.

The invention relates to a chlorpromazine hydrochloride synthesis process, which includes the steps: leading 2-chlorophenothiazine of a primary ring and a side chain of N, N-dimethyl-3-chloropropylamine, which serve as raw materials, to react with sodium hydroxide and tetrabutylammonium bromide, which serve as condensing agent, to generate chlorpromazine; and salifying the chlorpromazine and hydrogen chloride so that chlorpromazine hydrochloride is synthesized. By means of selecting the sodium hydroxide and the tetrabutylammonium bromide as the condensing agent, and strictly controlling the raw material ratio and an indicator end point of salifying reaction, molar yield of the chlorpromazine can be higher than 90%, and the quality of the chlorpromazine hydrochloride meets the requirements of the BP (British Pharmacopoeia).

The invention discloses a chlorpromazine hydrochloride chewable tablet used for dogs and cats. The invention can overcome the disadvantage of the poor palatability of the existing tablets, promote dogs and cats to chew and adsorb fully, effectively ensure the dosage of administration, enhance the cure rate of feline or canine diseases and reduce the waste of medicine. The tablet of the invention includes the following components represented by weight-percentage respectively: 1-5 percent of aspartame, 20-30 percent of the mixture of oral glucose and skim milk powder, in which the ratio of oral glucose and skim milk powder is 1:1-1:4, 40-60 percent of excipient, 0.5-1 percent of glidant and 5-20 percent of chlorpromazine hydrochloride.

The invention belongs to the technical field of medicine and discloses a lens anterior capsule staining method for hypermature cataract surgery. 240 Clean-level male Wistar rats weighing 200-250 g aretaken; the rats are randomly divided into a normal control group and an experiment group; compound tropicamide eye drops are used to dilate pupils of the experiment group three times before surgery,muscular injection is performed with ketamine hydrochloride and chlorpromazine hydrochloride mixture for anesthesia before superior corneal limbus incising is performed, the anterior chamber is injected with methylthioninium chloride injection, and after the injection stays in the anterior chamber, full irrigating is performed with compound sodium chloride injection; suitable viscoelastic agent isinjected, and continuous circular capsulorhexis is performed to observe tissue contrast; capsulotomy vannas scissors are used to perform cutting and trimming before capsulorhexis is continued. Additional preparations are not required herein; using is available at any time; biocompatibility is good; no pharmaceutical chemical toxicity is caused to intraocular tissues, such as corneal endothelial cells and visual cells; residual trace can be discharged by means normal intraocular absorption or aqueous circulation; no evident complications occur.

The invention discloses a preparation method of chlorpromazine hydrochloride polycystic sustained-release granules. The method includes the steps of S1, preparing first solution; S2, preparing second solution; S3, preparing third solution; S4, preparing final solution; S5, stirring and drawing pressure; S6 freeze drying. The preparation method has the advantages that the sustained-release granules are prepared by using degradable polymer materials to entrap chlorpromazine, medicine is wrapped in the sustained-release granules to form the polycystic granules even in granule size, the medicine is released in a sustained manner, disintegration, causing medicine burst release, of the granules is avoided after the granules are degraded in vivo for a certain time, and the method is simple to operate, convenient in preparation, low in cost and suitable for large-scale industrial production.

The invention discloses a preparation method of a supermolecule globular micelle based on an antidepressant medicament chlorpromazine. The method comprises the following steps: constructing a medicament carrier through the supermolecule interaction of amphiphilic sulfonated calix [4] arene and an antidepressant medicament chlorpromazine hydrochloride, dissolving the amphiphilic sulfonated calix [4] arene and the antidepressant medicament chlorpromazine hydrochloride in water, and uniformly mixing to obtain a nano supermolecule globular micelle solution; and non-covalently modifying a targeting agent trimethyl chitosan through a bonding site of the calix arene on the surface of the micelle to obtain the supermolecule micelle loaded with trimethyl chitosan on the surface. The preparation method has the advantages that the preparation method is simple and convenient, and fewer subjective and objective raw materials are used; the medicament load rate is high since the medicament molecules are the constructing units of the medicament carrier and the medicament molecules are immobilized; the micelle can be used for non-covalently modifying the targeting agent trimethyl chitosan through the bonding site of the surface calix arene so that the micelle has a wide application prospect in the field of targeted medicament delivery.

The invention discloses a preparation method of chlorpromazine hydrochloride multicapsule sustained-release granules, which comprises the following steps: S1. preparation of the first solution; S2. preparation of the second solution; S3. preparation of the third solution; S4. Preparation of the final solution; S5. Stirring and pumping; S6. Freeze-drying. The present invention uses the degradable macromolecule material to carry chlorpromazine to make drug slow-release granules, so that the drug can be wrapped in the slow-release granules to form multi-vesicle-structured granules with uniform particle size and gentle drug release. After degrading for a period of time, disintegration will not occur to cause drug burst release. The method of the invention is simple in operation, convenient in preparation, low in cost and suitable for large-scale industrial production.

The invention relates to a method for determining residual medicaments in mutton, and in particular relates to a method for determining multiple sedative type medicaments in mutton at the same time. The residual sedative type veterinary medicaments refer to zolpidem, haloperidol, chlordiazepoxide, promethazine, nitrazepam, chlorpromazine hydrochloride, perphenazine, fluphenazine hydrochloride, clonazepam, xylazine hydrochloride, propionylpromazine, carazolol, acepromazine, droperidol and azaperone. The method has the advantage that the residual amounts of 15 types of sedative type medicaments in mutton are determined through high-resolution liquid chromatography-tandem mass spectrometry. The method is high in sensitivity and high in recovery rate, and can meet the detection requirements on veterinary medicaments.

The invention belongs to the field of medical technology, and discloses a method for staining the anterior lens capsule in overmature cataract surgery. Take 240 clean-grade male Wistar rats with a body weight of 200-250 g; the animals are randomly divided into a normal control group and an experimental group; The experimental group was dilated with compound tropicamide eye drops three times before operation, anesthetized by intramuscular injection of a mixture of ketamine hydrochloride and chlorpromazine hydrochloride, then made an upper limbal incision, injected methylene blue injection into the anterior chamber, and stayed in the anterior chamber Afterwards, fully flush with compound sodium chloride injection; inject appropriate amount of viscoelastic agent, continuously circular capsulorhexis, observe tissue contrast; continue capsulorhexis after trimming with capsular shears. The present invention does not require additional preparation, can be taken at any time, and has good biocompatibility; it has no drug chemical toxicity to intraocular tissues, such as corneal endothelial cells and visual cells; residual traces can be discharged through normal intraocular absorption or aqueous humor circulation; no Obvious complications.

The invention discloses a supplemental detection method of seven chemical medicines including carbamazepine, chlorpromazine hydrochloride, olanzapine, doxepin hydrochloride, quetiapine fumarate, oxcarbazepine and sulpiride which are illegally added into health-care food or Chinese patent medicine for improving sleep. After a sample is subjected to ultrasonic extraction with methyl alcohol, chromatogram column separation is conducted, a mobile phase is eluted, and DAN detector is used for detection. By means of a built detection method, methodological verification is conducted, and parameters of results are shown in the description. It is verified that the method is quick, high in specificity and suitable for detection of chemical medicine added to the health-care food or Chinese patent medicine for improving sleep.

The invention belongs to the technical field of transporting commercial animals, and provides a method for processing a mixed medicament for relieving long-distance transportation stress response of commercial animal, especially water buffalo ox. The method is characterized by comprising the following steps by weight: applying 1mg / kg chlorpromazine hydrochloride plus 1g / kg white spirit with alcoholic strength of 50 degrees (V / V) or 1mg / kg chlorpromazine hydrochloride plus 2g / kg white spirit with alcoholic strength of 50 degrees (V / V) or 1mg / kg chlorpromazine hydrochloride plus 3g / kg white spirit with alcoholic strength of 50 degrees (V / V) to transported animal in transportation of animals before second hour. After being determined by transportation stress indexes such as growth indexes of weightlessness and average daily gain, body mass indexes of heart rate and respiratory rate and body temperature, immunity index WBC (White Blood Count) and behavior index of ingestion times and the like, the weight recovery period after long-distance transportation stress is determined to be at least 9d, and adverse reaction drugs measures for relieving the transportation stress can be provided. The method can be used for avoiding damage of long-distance transportation stress to the health and welfare.

The invention relates to a preparation method of chlorpromazine hydrochloride, and belongs to the technical field of medicine preparation. According to the method, 2-chlorophenothiazine and N, N-dimethyl-3-chloropropylamine are used as raw materials, an N-methyl pyrrolidone organic solvent is adopted, chlorpromazine is generated under the action of a 4-dimethylaminopyridine catalyst, the obtained chlorpromazine and hydrogen chloride gas are salified, and chlorpromazine hydrochloride is obtained. According to the method, a toxic toluene reagent is not needed, and an N-methyl pyrrolidone organic solvent is adopted, so that the method is more environment-friendly, and is more beneficial to recovery of chlorpromazine, and the yield and purity of chlorpromazine are improved. A large amount of sodium hydroxide does not need to be added, sodium hydroxide and tetrabutylammonium bromide in an original process can be replaced by selecting 4-dimethylaminopyridine, and the yield and purity of chlorpromazine hydrochloride are remarkably improved. By controlling the conditions of the salt forming reaction of hydrochloric acid, the crystallization and purification of chlorpromazine hydrochloride are facilitated, and high-purity chlorpromazine hydrochloride can be obtained.

The present invention discloses an analysis method for determining content of palladium in waste residues. The analysis method comprises the following steps: calcining a waste residue sample at high temperature, cooling to room temperature, adding a mixed solution of hydrochloric acid and nitric acid, heating at low temperature until the mixed solution is slightly boiled, sequentially adding sodium chloride and 10% hydrochloric acid, completely dissolving, transferring into a 100ml volumetric flask, and diluting with distilled water to a scale to obtain a pretreated sample solution; adding 1ml of the pretreated sample solution into a 60ml separating funnel, adding 20ml of water, adjusting the pH value to be 2 by using a 5% hydrochloric acid solution and a 5% sodium hydroxide solution, adding 2ml of a 1% chlorpromazine hydrochloride solution, uniformly shaking and standing for 10min to generate a red complex, adding 10ml of trichloromethane, carrying out oscillation extraction for 1min, taking a lower trichloromethane solution after layering, and taking reagent blank as a reference; and measuring the absorbance of the solution at 488 nm by using a 1 cm cuvette, and calculating the palladium content according to the absorbance and the standard regression curve. The method is low in detection cost and can be suitable for detecting the content of 0.1%-5% palladium.

The invention relates to a preparation method of chlorpromazine hydrochloride, which belongs to the technical field of medicine preparation. The present invention takes 2-chlorophenothiazine and N, N-dimethyl-3-chloropropylamine as raw materials, adopts N-methylpyrrolidone organic solvent, reacts under the effect of 4-dimethylaminopyridine catalyst, and generates chlorine Promethazine, the gained chlorpromazine and hydrogen chloride gas form a salt, namely get chlorpromazine hydrochloride. The present invention does not need to use toluene toxic reagent, and adopts N-methylpyrrolidone organic solvent, which is not only more environmentally friendly, but also more conducive to the recovery of chlorpromazine, and improves the yield and purity of chlorpromazine. And without adding a large amount of sodium hydroxide, by selecting 4-dimethylaminopyridine, it can replace sodium hydroxide and tetrabutylammonium bromide in the original process, and significantly improve the yield and purity of chlorpromazine hydrochloride. Controlling the conditions of the hydrochloric acid salt-forming reaction is more favorable for the crystallization and purification of chlorpromazine hydrochloride, and higher purity chlorpromazine hydrochloride can be obtained.