Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of chlorpromazine hydrochloride polycystic sustained-release granules

A technology of chlorpromazine hydrochloride and sustained-release granules, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, capsule delivery, etc. It can solve problems such as high utilization rate, disintegrating drugs, and inconvenience. Achieve the effect of low cost, convenient preparation and simple operation

Active Publication Date: 2015-12-09
嘉兴天源药业有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The utilization rate of chlorpromazine through injection treatment is high, but high-frequency injection treatment brings a lot of inconvenience. Therefore, degradable polymer materials can be used to encapsulate chlorpromazine to make drug sustained-release microspheres, but ordinary drug-loaded microspheres are in After a period of degradation in the body, disintegration will occur, resulting in burst release of the drug

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of chlorpromazine hydrochloride polycystic sustained-release granules
  • Preparation method of chlorpromazine hydrochloride polycystic sustained-release granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: A preparation method of chlorpromazine hydrochloride multicapsule sustained-release granule, it may further comprise the steps:

[0026] S1. Preparation of the first solution: Sodium hydroxide is added to the phosphate buffer solution in which chlorpromazine hydrochloride is dissolved, and the content of sodium hydroxide in the initial solution is 0.5%; an initial solution is formed, and the copolymer is poured into the initial solution In, the first solution is formed; wherein, the copolymer is a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer with a polyoxyethylene content of 69%, and the content of the copolymer in the first solution is 65% %; The content of chlorpromazine hydrochloride in the phosphate buffer saline solution that is dissolved with chlorpromazine hydrochloride is 0.8%;

[0027] S2. Preparation of the second solution: dissolving the biodegradable polymer material in an organic solvent to form a second solution; wherein...

Embodiment 2

[0032] Example 2: A preparation method of chlorpromazine hydrochloride multicapsule sustained-release granule, it may further comprise the steps:

[0033] S1. Preparation of the first solution: Add chlorpromazine hydrochloride-dissolved phosphate buffer, and the content of potassium hydroxide in the initial solution is 3%; form the initial solution, pour the copolymer into the initial solution to form The first solution; wherein, the copolymer is a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer with a polyoxyethylene content of 73%, and the content of the copolymer in the first solution is 75%; The content of chlorpromazine hydrochloride in the phosphate buffer that is dissolved with chlorpromazine hydrochloride is 2.7%;

[0034] S2. Preparation of the second solution: dissolving the biodegradable polymer material in an organic solvent to form a second solution; wherein, the biodegradable polymer material is a poly(lactic-co-glycolic acid) copolymer, and...

Embodiment 3

[0039] Example 3: A preparation method of chlorpromazine hydrochloride multicapsule sustained-release granule, it may further comprise the steps:

[0040] S1. Preparation of the first solution: Add alkali to the phosphate buffer solution that is dissolved with chlorpromazine hydrochloride to form an initial solution, and pour the copolymer into the initial solution to form the first solution; wherein, the copolymer is poly Oxyethylene content is 70% polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer, and the content of copolymer in the first solution is 68%; The alkali is sodium hydroxide and potassium hydroxide, weight Ratio is 1:2, and the content of alkali in initial solution is 1%; The content of chlorpromazine hydrochloride is 1.2% in the described phosphate buffered saline solution that is dissolved with chlorpromazine hydrochloride;

[0041] S2. Preparation of the second solution: dissolving the biodegradable polymer material in an organic solvent to ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of chlorpromazine hydrochloride polycystic sustained-release granules. The method includes the steps of S1, preparing first solution; S2, preparing second solution; S3, preparing third solution; S4, preparing final solution; S5, stirring and drawing pressure; S6 freeze drying. The preparation method has the advantages that the sustained-release granules are prepared by using degradable polymer materials to entrap chlorpromazine, medicine is wrapped in the sustained-release granules to form the polycystic granules even in granule size, the medicine is released in a sustained manner, disintegration, causing medicine burst release, of the granules is avoided after the granules are degraded in vivo for a certain time, and the method is simple to operate, convenient in preparation, low in cost and suitable for large-scale industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical technology and polymer technology, and in particular relates to a preparation method of chlorpromazine hydrochloride multicapsule sustained-release granules. Background technique [0002] At present, the number of mental patients in the world is constantly increasing. According to the prediction of the World Health Organization, by 2020, mental illness will become one of the five major diseases that make people lose their ability to work, and will seriously affect the development of the world. [0003] According to the data provided by the Mental Health Center of the Chinese Center for Disease Control and Prevention in early 2009, the number of patients with various mental disorders in my country is more than 100 million. At present, there are as many as 16 million severe mental patients in the country, and reports about mental patients harming or being injured have appeared frequently. In recent yea...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/32A61K47/34A61K31/5415A61P25/18
Inventor 朱雪标姜晓磊许少辉刘明秋
Owner 嘉兴天源药业有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com