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Simultaneous detection of 7 kinds of sleep chemicals detection method

A chemical drug and detection method technology, applied in the field of medicine, can solve the problem of no illegal addition of chemical drugs, and achieve fast, efficient, high-throughput analysis, high repeatability, and good repeatability

Active Publication Date: 2018-05-25
SHANXI PROVINCE FOOD & DRUG INSPECTION INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Whether there are other chemicals added to sleep aid health food, especially health food that does not contain melatonin, this problem cannot be solved with existing supplementary inspection methods, and there is no detection method for the illegal addition of the above-mentioned chemicals in literature reports. Therefore, the applicant has established a new supplementary test method for 7 kinds of chemicals with sleep function, for the application of illegal addition screening work

Method used

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  • Simultaneous detection of 7 kinds of sleep chemicals detection method
  • Simultaneous detection of 7 kinds of sleep chemicals detection method
  • Simultaneous detection of 7 kinds of sleep chemicals detection method

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Experimental program
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Embodiment Construction

[0041] Specific embodiments of the present invention will be described in detail below.

[0042] A detection method for simultaneous detection of 7 kinds of sleep chemicals

[0043] 1. Materials

[0044] 1.1. Instrument

[0045] Dianne U3000 high performance liquid chromatography, MS-204s one ten thousandth electronic balance, DV215CD one hundred thousandth electronic balance, ultrasonic extractor.

[0046] 1.2. Reagents

[0047] Potassium dihydrogen phosphate, analytical grade; methanol, analytical grade (extraction), chromatography pure (mobile phase); hydrochloric acid, analytical grade.

[0048] Control substance:

[0049] Carbamazepine, batch number: 100142-20110S, specification: 100mg, content 99.8%. Source: China National Institutes for Food and Drug Control.

[0050] Quetiapine fumarate, batch number: 100815-201202, specification: 100mg, content 99.9%. Source: China National Institutes for Food and Drug Control.

[0051] Chlorpromazine hydrochloride, batch numb...

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Abstract

The invention discloses a supplemental detection method of seven chemical medicines including carbamazepine, chlorpromazine hydrochloride, olanzapine, doxepin hydrochloride, quetiapine fumarate, oxcarbazepine and sulpiride which are illegally added into health-care food or Chinese patent medicine for improving sleep. After a sample is subjected to ultrasonic extraction with methyl alcohol, chromatogram column separation is conducted, a mobile phase is eluted, and DAN detector is used for detection. By means of a built detection method, methodological verification is conducted, and parameters of results are shown in the description. It is verified that the method is quick, high in specificity and suitable for detection of chemical medicine added to the health-care food or Chinese patent medicine for improving sleep.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to carbamazepine, chlorpromazine hydrochloride, olanzapine, doxepin hydrochloride, quetiapine fumarate, and oxcarbazepine illegally added to sleep-improving health foods or Chinese patent medicines , sulpiride and other 7 kinds of chemical detection methods. Background technique [0002] Due to the accelerated pace of life and increased work pressure, there are more and more insomnia patients in society, and the number of people who use drugs to improve sleep is also increasing. Many people think that the side effects of health food are small and the effect is mild, and they are willing to buy health food to improve sleep quality. However, criminals illegally add sedative and hypnotic chemical drugs in health food or Chinese patent medicine in order to achieve the effect of rapid treatment of insomnia. [0003] Such drugs often cause quite serious adverse reactions, and have drug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 董培智郭景文申国华施怀生王子龙
Owner SHANXI PROVINCE FOOD & DRUG INSPECTION INST
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