5 results about "Oxidative decarboxylation" patented technology

The present invention relates to a method for electrochemical oxidative decarboxylation of Fmoc-protected alpha-amino acids in a solvent mixture comprising an oxidizable solvent in the presence of a base.

A process for the preparation of isoprenol comprises the steps of a-i) preparing isobutylene by oxidizing isoamyl alcohol to isovaleric acid, and subjecting the isovaleric acid to oxidative decarboxylation so as to obtain isobutylene; and a-ii) reacting at least one formaldehyde source and the isobutylene obtained in step a-i) to obtain isoprenol. The process allows for providing isobutylene for the preparation of isoprenol and its downstream products, including prenol, prenal, isoprenal and / or 3,7-dimethyl-octa-2,6-dienal (citral), from renewable sources.

This invention discloses a method for synthesizing 3-oxa[3.1.1]spiropropane, belonging to the fields of organic synthetic chemistry and medicinal chemistry. This method is the first to introduce oxygen atoms into the high-strength skeleton of [3.1.1]spiropropane, successfully synthesizing the 3-oxa[3.1.1]spiropropane molecule. The specific synthetic route is as follows: starting with 3,3-bis(bromomethyl)oxacyclobutane, the 3-oxabicyclo[3.1.1]heptane diol skeleton is constructed sequentially via nucleophilic substitution with diethyl malonate, reduction, and intramolecular cyclization. Then, oxidation and Barton decarboxylation iodination are performed to obtain the key intermediate 1,3-diiodo-3-oxabicyclo[3.1.1]heptane, which is finally reacted with an organolithium reagent to obtain the target product. This invention fills a technological gap in the synthesis of heteroatom-substituted spiroalkyl, providing a key precursor for the subsequent development of its free radical bifunctionalization reaction and the construction of structurally diverse 3-oxabicyclic [3.1.1]heptane dominant skeletons. It has important application prospects in drug design, especially as a bio-electroisoster of meta-substituted aromatics.

The invention belongs to the technical field of photocatalytic material preparation, and relates to a preparation method and application of a decatungstate-containing hybrid material, in particular to application of the decatungstate-containing hybrid material in a photocatalytic aryl acetic acid decarboxylation reaction. The preparation method comprises the following steps: taking N, N '-bis (3, 5-dimethyl-1H-2-pyrrolyl)-1, 4, 5, 8-naphthalimide, tetrabutyl phosphonium decatungstate and zinc nitrate hexahydrate as raw materials, stirring in a mixed solvent, and standing to obtain the decatungstate-containing hybrid material. The material has the advantages of higher thermal stability, low requirement on synthesis equipment, simplicity and convenience in operation, low cost and large-scale production, can be used for catalyzing the oxidative decarboxylation reaction of aryl acetic acid to generate corresponding aryl formaldehyde under the irradiation of visible light, has the characteristics of high conversion rate and high chemical stability, and is suitable for industrial production. And the catalyst has extremely high catalytic activity for converting aryl acetic acid into aryl formaldehyde through oxidative decarboxylation.

The application discloses a method for preparing ethylene by decarboxylation of succinic acid through square-wave electro-oxidation with polarity alternation, and belongs to the technical field of new energy chemical industry. In order to eliminate the problems of catalyst deactivation and rapid poisoning, a graphite sheet is used as a working electrode in an electrolytic system, and a succinate aqueous solution is used as a substrate in an electrolyte. Square-wave alternating current with polarity alternation is applied between the working electrode and a counter electrode, so that ethylene and hydrogen are prepared through electro-catalysis. The application can effectively maintain the activity of the catalyst, accurately control the reaction path, complete the conversion from the Kolbe dimerization to the non-Kolbe path with high selectivity for generating ethylene, realize the efficient and continuous conversion of the succinic acid electro-oxidation decarboxylation for preparing ethylene, and is expected to be applied to actual production.