2 results about "Oxidative decarboxylation" patented technology

This invention discloses a method for synthesizing 3-oxa[3.1.1]spiropropane, belonging to the fields of organic synthetic chemistry and medicinal chemistry. This method is the first to introduce oxygen atoms into the high-strength skeleton of [3.1.1]spiropropane, successfully synthesizing the 3-oxa[3.1.1]spiropropane molecule. The specific synthetic route is as follows: starting with 3,3-bis(bromomethyl)oxacyclobutane, the 3-oxabicyclo[3.1.1]heptane diol skeleton is constructed sequentially via nucleophilic substitution with diethyl malonate, reduction, and intramolecular cyclization. Then, oxidation and Barton decarboxylation iodination are performed to obtain the key intermediate 1,3-diiodo-3-oxabicyclo[3.1.1]heptane, which is finally reacted with an organolithium reagent to obtain the target product. This invention fills a technological gap in the synthesis of heteroatom-substituted spiroalkyl, providing a key precursor for the subsequent development of its free radical bifunctionalization reaction and the construction of structurally diverse 3-oxabicyclic [3.1.1]heptane dominant skeletons. It has important application prospects in drug design, especially as a bio-electroisoster of meta-substituted aromatics.

The application discloses a method for preparing ethylene by decarboxylation of succinic acid through square-wave electro-oxidation with polarity alternation, and belongs to the technical field of new energy chemical industry. In order to eliminate the problems of catalyst deactivation and rapid poisoning, a graphite sheet is used as a working electrode in an electrolytic system, and a succinate aqueous solution is used as a substrate in an electrolyte. Square-wave alternating current with polarity alternation is applied between the working electrode and a counter electrode, so that ethylene and hydrogen are prepared through electro-catalysis. The application can effectively maintain the activity of the catalyst, accurately control the reaction path, complete the conversion from the Kolbe dimerization to the non-Kolbe path with high selectivity for generating ethylene, realize the efficient and continuous conversion of the succinic acid electro-oxidation decarboxylation for preparing ethylene, and is expected to be applied to actual production.