Preparation method of benzoazepine compounds

Abstract

The invention discloses a preparation method of benzoazepine compounds. The method comprises the following steps: reacting under a metal-free catalytic reaction condition, a N-aryl acrylamide compoundand a 4-alkenyl alkyl carboxylic acid compound are subjected to oxidation decarboxylation / cyclization to prepare a series of benzoazepine compounds. The method has advantages of mild reaction condition, simple operation, economy, green property, low cost and the like, and a convenient and effective approach is provided for the synthesis of benzoazepine compounds.

Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, and specifically relates to a benzazepine Method for the preparation of compounds. Background technique

[0002] In modern organic synthesis, cycloaddition reactions are the efficient and most direct atom-economical methods for constructing carbon- and / or heterocyclic skeletons. However, most cycloaddition reactions focus on well-developed five-membered or six-membered ring systems, and the development of seven-membered rings, especially seven-membered nitrogen-containing heterocycles such as aza Compound-like compounds remain a major challenge in the field of organic synthesis. Aza Compound-like compounds have attracted the attention of chemists in the past few years, and this is because their core structures widely exist in natural products, drugs, and functional intermediates with important biological activities (see DE19910403A1; CN109071450A), so , organic synthetic chemists...

Images