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Compound preparation for treating depression

A technology of compound preparations and inhibitors, which is applied in the field of medicine to achieve the effect of improving curative effect and reducing side effects

Active Publication Date: 2015-12-23
SICHUAN JIUZHANG BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chlorogenic acid has been widely used in many fields such as food, health care products, cosmetics and pharmaceuticals, such as: cardiovascular protection, anti-oxidation, anti-ultraviolet and anti-radiation effects, anti-mutagenic and anti-cancer effects, antibacterial effects, Antiviral effects, lipid-lowering and hypoglycemic effects, immune regulation effects, etc., but other effects of chlorogenic acid need further research and exploration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Synergistic antidepressant effect of chlorogenic acid and imipramine

[0020] 1. Experimental materials

[0021] ICR mice, half male and half female, body weight 20±2g. Breeding conditions: air-conditioned room, temperature 18-24 ℃, relative humidity 70%.

[0022] 2. Experimental method

[0023] (1) Animal grouping: 50 ICR mice were randomly divided into 5 groups, 10 in each group.

[0024] Chlorogenic acid group: intraperitoneal injection of chlorogenic acid for 14 consecutive days.

[0025] Imipramine group: intraperitoneal injection of imipramine for 14 consecutive days.

[0026] Chlorogenic acid and imipramine combination group (mass ratio: 1:1): chlorogenic acid was administered intraperitoneally first, and imipramine was administered intraperitoneally 30 minutes later; the administration continued for 14 days.

[0027] Chlorogenic acid and imipramine combination group (mass ratio: 1:2): Chlorogenic acid was given intraperitoneal injection first, and imipramin...

Embodiment 2

[0035] Effects of Chlorogenic Acid and Compound Preparations on the Spontaneous Activities of Mice

[0036] 1. Experimental materials

[0037] ICR mice, half male and half female, body weight 20±2g. Breeding conditions: air-conditioned room, temperature 18-24 ℃, relative humidity 70%.

[0038] 2. Experimental method

[0039] (1) Animal grouping: 50 ICR mice were randomly divided into 5 groups, 10 in each group.

[0040] Chlorogenic acid group: intraperitoneal injection of chlorogenic acid for 14 consecutive days.

[0041] Imipramine group: intraperitoneal injection of imipramine for 14 consecutive days.

[0042] Chlorogenic acid and imipramine combination group (mass ratio: 1:1): chlorogenic acid was administered intraperitoneally first, and imipramine was administered intraperitoneally 30 minutes later; the administration continued for 14 days.

[0043] Chlorogenic acid and imipramine combination group (mass ratio: 1:2): Chlorogenic acid was given intraperitoneal injecti...

Embodiment 3

[0050] Synergistic antidepressant effect of chlorogenic acid and fluoxetine

[0051] 1. Experimental materials

[0052] ICR mice, half male and half female, body weight 20±2g. Breeding conditions: air-conditioned room, temperature 18-24 ℃, relative humidity 70%.

[0053] 2. Experimental method

[0054] (1) Animal grouping: 50 ICR mice were randomly divided into 5 groups, 10 in each group.

[0055] Chlorogenic acid group: intraperitoneal injection of chlorogenic acid for 14 consecutive days.

[0056] Fluoxetine group: intraperitoneal injection of fluoxetine for 14 consecutive days.

[0057] Chlorogenic acid and fluoxetine combination group (mass ratio: 1:2): Chlorogenic acid was administered intraperitoneally first, followed by intraperitoneal injection of fluoxetine 30 minutes later; continuous administration for 14 days.

[0058] Chlorogenic acid and fluoxetine combination group (mass ratio: 1:4): Chlorogenic acid was administered intraperitoneally first, followed by intra...

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PUM

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Abstract

The invention provides a compound preparation for treating depression, and belongs to the technical field of medicines. The active ingredients of the compound preparation comprise conventional antidepressant and chlorogenic acid, wherein the conventional antidepressant is a selective serotonin reuptake inhibitor or tricyclic and heterocyclic antidepressants. According to the compound preparation, the conventional antidepressant and chlorogenic acid serving as active ingredients are synergized, so that the side effect of the conventional antidepressant can be reduced, and the curative effect can be improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound preparation for treating depression. Background technique [0002] Depression is a very common disease. About 10% of the population will suffer from different degrees of depression during certain periods of their lives, and patients with depression often have serious suicidal tendencies. According to surveys, more than 30,000 people in the United States commit suicide every year. Depression is thought to be a major factor. [0003] Currently commonly used antidepressants include serotonin reuptake inhibitors, tricyclic and heterocyclic antidepressants, etc., but there are generally defects such as long clinical treatment cycle, asynchronous target effect and symptom improvement, and serious side effects. . [0004] Chlorogenic acid is a phenolic acid composed of caffeic acid and quinic acid. caffeoylquinicacid) is a benzene compound produced by plants through the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61P25/24A61K31/216
Inventor 张洁朱丽娜
Owner SICHUAN JIUZHANG BIO TECH CO LTD