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Method for extracting fat oil in croton by using ionic liquid

A technology of ionic liquid and fatty oil, which is applied in the direction of fat production, fat oil/fat production, and pharmaceutical formulations. It can solve the problems of waste of medicinal material resources, inability to fully extract effective ingredients such as croton oil, and a large proportion of croton. It is easy to recycle and good Dissolvability and the effect of less loss of content

Inactive Publication Date: 2015-12-23
HENAN XINGZHI PATENT SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method cannot fully extract the active ingredient croton oil, resulting in a relatively large proportion of croton in the preparation prescription. The use of croton in this patent will cause a waste of medicinal material resources

Method used

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  • Method for extracting fat oil in croton by using ionic liquid
  • Method for extracting fat oil in croton by using ionic liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A method utilizing ionic liquid to extract fatty oil in croton comprises the following steps:

[0022] (1) Peel the croton seeds, take 10 g of the seed kernels, process them, and crush them to obtain processed crotons; the processing method is as follows: heat an empty pot, stir-fry the croton kernels, and fry until the cross-section of the croton kernels is When the yellow-white color turns into brown-yellow, take it out quickly and cool down;

[0023] (2) Add 80 mL of ionic liquid ethanol solution to the croton processed product in step (1), mix well, and the ionic liquid is BmimCF 3 SO 3 , with a concentration of 0.3mol / L, reacted at 50°C for 10h to obtain a mixed solution;

[0024] (3) Microfilter the mixture in step (2), collect the filtrate, and remove ethanol;

[0025] (4) The filtrate is separated by column chromatography, 200-300 mesh silica gel column, the eluent is petroleum ether and acetone, the volume ratio of the two is 1:1-10:1, concentrated under red...

Embodiment 2

[0027] A method utilizing ionic liquid to extract fatty oil in croton comprises the following steps:

[0028] (1) Peel the croton seeds, take 12g of the seed kernels, process them, and crush them to obtain processed crotons; the processing method is as follows: heat an empty pan, stir-fry the croton kernels, and fry until the cross-section of the croton kernels is When the yellow-white color turns into brown-yellow, take it out quickly and cool down;

[0029] (2) Add 90 mL of ionic liquid ethanol solution to the croton processed product in step (1), mix well, and the ionic liquid is BmimPF 6 , with a concentration of 0.4mol / L, reacted at 55°C for 8 hours to obtain a mixed solution;

[0030] (3) Microfilter the mixture in step (2), collect the filtrate, and remove ethanol;

[0031] (4) The filtrate is separated by column chromatography, 200-300 mesh silica gel column, the eluent is petroleum ether and acetone, the volume ratio of the two is 1:1-10:1, concentrated under reduce...

Embodiment 3

[0033] A method utilizing ionic liquid to extract fatty oil in croton comprises the following steps:

[0034] (1) Peel the croton seeds, take 15 g of the seed kernels, process them, and crush them to obtain the processed croton products; When the yellow-white color turns into brown-yellow, take it out quickly and cool down;

[0035] (2) Add 100 mL of ionic liquid ethanol solution to the croton processed product in step (1), mix well, and the ionic liquid is BmimSbF 6 , with a concentration of 0.42mol / L, reacted at 60°C for 7 hours to obtain a mixed solution;

[0036] (3) Microfilter the mixture in step (2), collect the filtrate, and remove ethanol;

[0037] (4) The filtrate was separated by column chromatography, concentrated under reduced pressure, and dried in vacuo to obtain 4.3 g of fatty oil.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine component extraction, and in particular discloses a method for extracting fat oil in croton by using an ionic liquid. The method comprises the following steps: preparing croton, extracting by using an ionic liquid ethanol solution, performing column chromatography isolation, performing vacuum concentration, and drying in vacuum, thereby obtaining fat oil. The method for extracting fat oil in croton by using the ionic liquid is green and environment-friendly, high in oil yield and simple in whole operation process, waste of traditional Chinese medicine resources can be reduced, the prepared croton fat oil can be directly used in medicines without boiling, and good economic and social benefits can be made.

Description

technical field [0001] The invention belongs to the technical field of extracting components of traditional Chinese medicinal materials, and in particular relates to a method for extracting fat oil in croton by using ionic liquid. Background technique [0002] Many Chinese medicinal materials contain a variety of biologically active compounds, which have a variety of curative effects and have a wide range of application values. Common active ingredients such as: polyphenolic compounds, nitrogenous compounds, vitamins, terpenoids and some other endogenous metabolites. The extraction methods commonly used for these active compounds include decoction, ultrasonic reflux, Soxhlet extraction, etc. However, in the experimental process of these methods, toxic organic solvents are used and the amount is large, the extraction takes a long time, and the extraction efficiency is low. Moreover, it is harmful to the health of the experimental operators and seriously pollutes the environm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C11B1/10A61K36/47
Inventor 马新攀
Owner HENAN XINGZHI PATENT SERVICE CO LTD
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