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Composition and method for preventing, reducing, alleviating, or treating idiopathic vomiting

A composition, idiopathic technology, applied in the direction of drug combination, application, animal feed, etc., can solve problems such as bad taste and side effects

Pending Publication Date: 2015-12-23
MARS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these compounds often cause side effects
Also, it is difficult to administer this class of compounds through feeding due to their unpleasant taste
Unfortunately, injections are not an appropriate alternative to administering antiemetics

Method used

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  • Composition and method for preventing, reducing, alleviating, or treating idiopathic vomiting
  • Composition and method for preventing, reducing, alleviating, or treating idiopathic vomiting
  • Composition and method for preventing, reducing, alleviating, or treating idiopathic vomiting

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0116] Screening Test for 5-HT3a Receptor Inhibitors

[0117] Various known high-throughput screening assays can be used to determine the inhibitory effect of a material on the 5-HT3a receptor.

[0118] For example, 5-HT3a receptors are ligand-gated nonselective cation channels located in the central and peripheral nervous systems. By inducing calcium and sodium influx and mobilizing intracellular calcium stores (calciumstore), as well as modulating various neurotransmitters and neuropeptides such as dopamine, cholecystokinin, acetylcholine, γ-aminobutyric acid (GABA), substance P or serotonin Release of itself, activates 5-HT3a receptors, followed by rapid depolarization of peripheral or central neurons, which leads to cytoplasmic Ca 2+ and Na + Concentration rises sharply. Since activation of the 5HT3 receptor is followed by calcium and sodium influx and a subsequent rapid increase in intracellular calcium and sodium, calcium indicators (such as Fluo-4AM) or sodium dyes...

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PUM

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Abstract

Compositions containing one or more compounds with inhibitory effect on a 5-HT3a and / or NK-1 receptor are effective for preventing or treating idiopathic vomiting in a mammal.

Description

field of invention [0001] The present invention relates to the prevention or treatment of In particular, dietary compositions or methods for idiopathic emesis in domestic cats. Background of the invention [0002] Chronic / periodic idiopathic emesis (emesis) or vomiting (vomiting) syndrome in cats was recognized in the late nineteenth century. While occasional vomiting is acceptable in cats under certain circumstances, such as when eating too quickly or too much or when there is excess hair or other foreign material in the stomach, frequent vomiting or regurgitation without cause ("idiopathic Vomiting") can lead to severe malnutrition in cats and lead to damage to the cat's gastrointestinal (GI) health. The four main features that define idiopathic vomiting or nausea are: 1) recurrent separated episodes of three or more episodes of vomiting or nausea; 2) a completely normal, healthy state with varying intervals between the episodes; 3) The periods are stereotypical in term...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K1/00A23L1/00A61K31/22A61K31/341A61K31/352A61K31/409A61K31/4353A61K31/4402
CPCA61K31/22A61K31/341A61K31/352A61K31/409A61K31/4353A61K31/4402A61K31/12A61K31/365A61K31/525A61K31/593A23K20/00A23K50/40A61K45/06A61P1/08A61P43/00A61P1/14A61K36/54
Inventor J·S·帕克P·胡Y·林L·A·雷因萨鲁
Owner MARS INC
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