HIB (Haemophilus influenzae type B) synthetic medium, HIB conjugate vaccine and preparation method of HIB conjugate vaccine
A Haemophilus influenzae-conjugated vaccine technology, which is applied in the field of vaccine production and preparation technology, can solve the problems of unstable Haemophilus influenzae type b conjugate vaccine, prone to allergic reactions, and high endotoxin content, and achieves stable strain passage, The effect of easy operation and simplified process steps
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Embodiment 1
[0051] Example 1 Preparation of HIB comprehensive medium
[0052] The components in the medium and their final concentration are: yeast extract powder 10g / l, glucose 10g / l, MgCl 2 ·6H 2 O2.03g / l, β-Coenzyme A 0.02g / l, Hemin 0.01g / l, Na 2 HPO 4 ·12H 2 O28.65g / l, NaH 2 PO 4 ·2H 2 O3.12g / l; Weigh the above substances according to the above ratio, fully dissolve them in an appropriate amount of sterile water for injection, and then make the volume constant, adjust the pH value within the range of 7.2 to 7.4, and obtain the HIB comprehensive medium. The medium does not contain blood-derived components and macromolecular allergic components.
Embodiment 2
[0053] Example 2 Preparation of HIB comprehensive medium
[0054] The components in the medium and their final concentration are: yeast extract powder 5g / l, glucose 15g / l, MgCl 2 ·6H 2 O3g / l, β-Coenzyme A 0.01g / l, hemin 0.02g / l, Na 2 HPO 4 ·12H 2 O22g / l, NaH 2 PO 4 ·2H 2 O5g / l; Weigh the above substances according to the above ratio, fully dissolve them in an appropriate amount of sterile water for injection, and then make the volume constant, adjust the pH value within the range of 7.2 to 7.4, and obtain the HIB comprehensive medium. The medium does not contain blood-derived components and macromolecular allergic components.
Embodiment 3
[0055] Example 3 Preparation of HIB comprehensive medium
[0056] The components in the medium and their final concentration are: yeast extract powder 15g / l, glucose 5g / l, MgCl 2 ·6H 2 O1g / l, β-Coenzyme A 0.03g / l, Hemin 0.005g / l, Na 2 HPO 4 ·12H 2 O32g / l, NaH 2 PO 4 ·2H 2 O2g / l; Weigh the above substances according to the above ratio, fully dissolve them in an appropriate amount of sterile water for injection, and then make the volume constant, adjust the pH value within the range of 7.2 to 7.4, and obtain the HIB comprehensive medium. The medium does not contain blood-derived components and macromolecular allergic components.
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