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Shortstalk monkshood root microemulsion and preparation method thereof

A production method and microemulsion technology, which is applied in the fields of pharmaceutical formula, emulsion delivery, and medical preparations containing active ingredients, etc., can solve problems such as poor water solubility and fat solubility, large microemulsion particle size, and unstable performance

Active Publication Date: 2016-01-06
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor water-solubility and fat-solubility of the total alkaloids of Artemisia spp. In the milk, the drug loading capacity of the total alkaloids of Artemisia japonica is relatively low, about 3mg / g, and the performance is not stable enough, the appearance is not clear enough, the particle size of the microemulsion is relatively large, generally exceeding 100nm, and the quality is poor

Method used

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  • Shortstalk monkshood root microemulsion and preparation method thereof
  • Shortstalk monkshood root microemulsion and preparation method thereof
  • Shortstalk monkshood root microemulsion and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0118] Formula: Xueshangzhi Artemisia total alkali 2g, isopropyl myristate 3.3g, polyoxyethylene 35 castor oil 19.8g, absolute ethanol 9.9gg and water 65g.

[0119] Process: After mixing the total alkaloids of Artemisia spp. and isopropyl myristate, ultrasonically treat for 15 minutes. After the drug is evenly dispersed, add polyoxyethylene 35 castor oil and absolute ethanol, and ultrasonically treat for 15 minutes. Stir while stirring Add water while adding water, and continue stirring after adding water until the solution becomes a transparent and clear microemulsion, that is, a microemulsion of Artemisia annua in snow.

Embodiment 2

[0121] Recipe: 2g total alkaloids of Artemisia japonica, 2g isopropyl myristate, 15g polyoxyethylene 35 castor oil, 5g absolute ethanol and 60g water.

[0122] Process: After mixing the total alkaloids of Artemisia spp. and isopropyl myristate, ultrasonically treat for 15 minutes. After the drug is evenly dispersed, add polyoxyethylene 35 castor oil and absolute ethanol, and ultrasonically treat for 15 minutes. Stir while stirring Add water while adding water, and continue stirring after adding water until the solution becomes a transparent and clear microemulsion, that is, a microemulsion of Artemisia annua in snow.

Embodiment 3

[0124] Recipe: Xueshangyi Artemisia total alkali 3g, isopropyl myristate 4g, polyoxyethylene 35 castor oil 25g, absolute ethanol 5g and water 60g.

[0125] Process: After mixing the total alkaloids of Artemisia spp. and isopropyl myristate, ultrasonically treat for 15 minutes. After the drug is evenly dispersed, add polyoxyethylene 35 castor oil and absolute ethanol, and ultrasonically treat for 15 minutes. Stir while stirring Add water while adding water, and continue stirring after adding water until the solution becomes a transparent and clear microemulsion, that is, a microemulsion of Artemisia annua in snow.

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Abstract

The invention discloses a shortstalk monkshood root microemulsion and a preparation method thereof. The microemulsion is mainly prepared from shortstalk monkshood root. The prepared microemulsion is excellent in transdermal absorption property, and the microemulsion is capable of improving the dissolution of water-insoluble medicines, promoting absorption of macromolecular medicines in a body and enhancing a penetration rate; the microemulsion also can form medicine reservoirs in cuticle and dermis, so that a significant sustained-release effect of the medicines is achieved; and the microemulsion is clear and transparent in appearance and is good in stability, and particle size of the microemulsion is 1-100nm.

Description

technical field [0001] The invention relates to an Artemisia chinensis microemulsion and a preparation method thereof, in particular to an Artemisia annua microemulsion with high drug loading and good quality and a preparation method thereof. technical background [0002] Aconitum brachypodum Diels is the dried root tuber of the Ranunculaceae plant Aconitum brachypodum Diels. It is warm in nature, bitter in taste, pungent, and highly toxic. It has the functions of dispelling wind and dampness, benefiting joints, reducing swelling and relieving pain. Its alkaloid components have the effects of promoting blood circulation, analgesia, and anti-inflammation. However, its therapeutic dose is very close to the poisoning dose, and improper use may lead to poisoning, arrhythmia and even shock. The transdermal administration of toxic traditional Chinese medicine is a major feature of the external treatment of traditional Chinese medicine. Compared with other administration routes, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K36/714A61P29/00
Inventor 陈晓兰
Owner 贵州中医药大学