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Medical applications of 20(S)-protopanoxadiol

A technology of protopanaxadiol and medicine, which is applied in the field of medical application of 20-protopanaxadiol, which can solve problems such as poor blood sugar control, cell reduction, and poor blood circulation

Inactive Publication Date: 2016-01-13
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the blood sugar control of diabetic patients is not good, and the body's ability to eliminate bacteria will be reduced
High blood sugar can reduce the ability of cells to transport oxygen to tissues, resulting in poor blood circulation and affecting wound healing

Method used

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  • Medical applications of 20(S)-protopanoxadiol
  • Medical applications of 20(S)-protopanoxadiol
  • Medical applications of 20(S)-protopanoxadiol

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach

[0033] 1. Experimental materials

[0034] 1.1 Medicinal materials

[0035] 20(S)-Protopanaxadiol (molecular weight: 460, HPLC purity ≥ 99%, Institute of Traditional Chinese Medicine)

[0036] 1.2 Experimental animals

[0037] db / db female mice (12 weeks) weighing 50±5 g were provided by the Experimental Animal Center of Shanghai University of Traditional Chinese Medicine, animal certificate number: SCXK (Shanghai) 2012-0002. Placed in a conventional feeding environment, housed in separate cages, free to eat and drink.

[0038] 2. Experimental method

[0039] 2.1 Establishment of diabetes injury model

[0040] Using the modeling method in the literature (Nature Protocols, 2013, 8:302-309), after isoflurane anesthesia, the back skin was shaved, depilatory cream was removed, and routine skin disinfection was used. A circular incision is made laterally, reaching deep to the fascia. To prevent automatic contraction of the wound, silicone gaskets (0.5 mm thick, inner diameter ...

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Abstract

The invention belongs to the field of medicine, and especially relates to medical applications of 20(S)-protopanoxadiol. It is confirmed by animal experiments that 20(S)-protopanoxadiol is capable of promoting wound healing of diabetes effectively, and 20(S)-protopanoxadiol possesses significant importance on treatment of diabetic gangrene.

Description

technical field [0001] The invention relates to the field of medicine and health care products, in particular to a medical application of 20(S)-protopanaxadiol. Background technique [0002] Diabetes is a metabolic disease that seriously threatens human health, and has become the fourth leading cause of death after cardiovascular, tumor and AIDS. Statistics show that there are currently 285 million diabetic patients in the world, and it is predicted that by 2030, the number of diabetic patients in the world will reach 439 million, and the complications caused by diabetes have become the main cause of disability and death of patients. Among the many complications of diabetes, the impaired wound healing ability of diabetic patients is a typical complication of diabetes. If chronic injuries and ulcers occur in the feet, it may cause diabetic foot, and even lead to amputation in severe cases. Diabetes is the disease with the highest hospitalization rate, and it is reported that...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/575A61P17/02A61P3/10A61P17/00A61P7/04A23L1/29A61K8/63A61Q11/00A61Q19/10
Inventor 王峥涛张二云高波吴晓俊杨莉
Owner SHANGHAI UNIV OF T C M
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