Preparation method and uses of aromatic oil complex encapsulation liposome
An aroma oil and compound technology, which is applied to the formulation of perfume preparations, essential oils/spice, medical preparations containing active ingredients, etc. Effect
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[0020] A method for preparing liposomes encapsulating aromatic oil complexes, comprising the preparation of aromatic oil mixture ingredients and liposomes, characterized in that: sequentially comprising the following steps:
[0021] (1) Material preparation: by mass percentage, lipid material 0.5%-8%, propylene glycol 2%-12%, aromatic oil compound 0.1%-10%, deionized water 70%-90%;
[0022] The lipid material is lecithin and cholesterol, the mass ratio of which is (2.5-4):1;
[0023] Rose essential oil, grapefruit essential oil, sweet orange essential oil and geranium essential oil are accurately weighed in a weight ratio of 5:3:1:1, placed in a test tube and vortexed for 3 minutes to prepare an aromatic oil compound.
[0024] (2) Preparation of lipid solution: Add the lecithin and cholesterol into propylene glycol in a 65° C. water bath with constant stirring until completely dissolved to make the solution clear. Then add the aromatic oil mixture, maintain a 65°C water bath ...
Embodiment 1
[0028] Embodiment 1 aroma oil compound preparation
[0029] Put rose essential oil, grapefruit essential oil, sweet orange essential oil and geranium essential oil in a weight ratio of 5:3:1:1, accurately weigh and place in a test tube, vortex for 3 minutes to mix evenly, and obtain an aromatic oil compound.
Embodiment 2
[0031] (1) Each component is prepared according to the following mass percentages: 0.4% lecithin, 0.1% cholesterol, 10.14% propylene glycol, 8% aromatic oil complex, and 81.36% deionized water. The aromatic oil complex is prepared according to the method of Example 1.
[0032] (2) Preparation of lipid solution: Add the lecithin and cholesterol into propylene glycol in a 65° C. water bath with constant stirring until the solution is completely dissolved and clear. Then add the aromatic oil mixture, maintain a 65°C water bath and keep stirring until the solution is clear;
[0033] (3) Gradually add the above-mentioned lipid solution into deionized water at 65°C while it is hot. During the addition process, maintain heating in a water bath at 65°C and keep stirring. After the lipid solution is completely added to the deionized water, continue to maintain 65°C °C water bath and stirred for 15 min, then stirred at room temperature for 0.5 h;
[0034] (4) The above mixture was sub...
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