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A method for improving curcumin water solubility and solution photostability

A technology of photostability and curcumin, applied in the separation/purification of carbonyl compounds, organic chemistry, etc., can solve the problems of curcumin's poor water solubility and solution photostability, so as to improve the utilization value, shorten the processing time and broaden the application field effect

Active Publication Date: 2017-06-16
苏州盛泽科技创业园发展有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problems of poor water solubility and poor photostability of curcumin, the object of the present invention is to provide a reasonable modification process and simple operation process, which can not only improve the solubility of curcumin in water, but also improve the photostability of curcumin in its aqueous solution. Methods

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  • A method for improving curcumin water solubility and solution photostability
  • A method for improving curcumin water solubility and solution photostability
  • A method for improving curcumin water solubility and solution photostability

Examples

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Embodiment 1

[0024] (1) Preparation of water-soluble reactive ultraviolet absorber: 100 g of cyanuric chloride was added to 1000 mL of ice water, stirred into a viscous slurry, 98 g of p-aminobenzenesulfonic acid was slowly added and kept for 90 minutes for reaction. After the reaction is completed, use a certain concentration of sodium hydroxide solution to adjust the pH value to 5-6, then raise the temperature to 60° C., add a certain amount of ethylenediamine, and keep the reaction for 2 hours. After the reaction is completed, adjust the pH value to 5-6 with a certain concentration of sodium hydroxide solution to obtain a white viscous liquid, which is a water-soluble reactive ultraviolet absorber. Then, the white viscous liquid is distilled under low temperature and reduced pressure to obtain solid powder of water-soluble reactive ultraviolet absorber.

[0025] (2) Curcumin modification: 2.5g curcumin is mixed with 2.3g water-soluble reactive ultraviolet absorber (mass ratio is 1.08), ...

Embodiment 2

[0029] (1) Preparation of water-soluble reactive ultraviolet absorber: same as Example 1.

[0030] (2) Curcumin modification: 2.5g curcumin is mixed with 4.5g water-soluble reactive ultraviolet absorber (mass ratio is 0.56), and sodium carbonate is added to adjust the pH of the reaction solution to 9.8, shake well and stand for 20 minutes The solution was placed in an oscillating water bath, and was shaken at a constant temperature of 65°C for 50 minutes. After the modified curcumin solution was left standing for 1 hour, the supernatant was taken, and the pH was adjusted to 4 with an acid solution to obtain a stable modified curcumin solution. After placing it under natural light for 10 days, the change of its absorbance was measured, and the results are shown in Table 3. Compared with unmodified curcumin, the solubility of modified curcumin in water increased significantly; moreover, after 10 days of natural light, the absorbance almost did not decrease, indicating that the ...

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Abstract

The invention relates to a method for improving water solubility of curcumin and solution photostability, in particular to a method for improving water solubility of curcumin and solution photostability by modifying curcumin through a water-soluble reaction type ultraviolet absorbing agent. A product obtained by chemically modifying curcumin through the water-soluble reaction type ultraviolet absorbing agent has good water solubility and photostability. The modification method provides a new means for solving the problem that water solubility of curcumin is poor. Meanwhile, a new thought is provided for improving photostability of curcumin, and the method has extremely wide application prospects.

Description

technical field [0001] The invention relates to a method for improving the water solubility and light stability of curcumin, in particular to a method for modifying curcumin with a water-soluble reactive ultraviolet absorber to improve the water solubility and light stability of curcumin, which belongs to natural Product modification and processing fields. Background technique [0002] Nowadays, many traditional industries are facing many problems such as restricted use of some toxic reagents, environmental pollution, increased labor costs, and poor market competitiveness. Out of the consideration of environmental protection and sustainable development, as well as people's pursuit of ecological products and green production processes, the utilization of natural products (including natural pigments) has come into people's field of vision again. Many natural pigments have advantages over synthetic pigments due to their good biodegradability, bio- and environmental compatibili...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C45/86C07C49/255
CPCC07C45/86C07C49/255
Inventor 唐人成周宇阳
Owner 苏州盛泽科技创业园发展有限公司