Copolymer using nano calcium phosphate coated polymethyl methacrylate as substrate and coating method thereof

A technology of polymethyl methacrylate and nano-calcium phosphate, which can be used in coatings, pharmaceutical formulations, dental preparations, etc., and can solve problems such as inability to bond to bones

Inactive Publication Date: 2016-02-10
NANO & ADVANCED MATERIALS INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] PMMA itself is biologically inert and cannot bind to bone

Method used

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  • Copolymer using nano calcium phosphate coated polymethyl methacrylate as substrate and coating method thereof
  • Copolymer using nano calcium phosphate coated polymethyl methacrylate as substrate and coating method thereof
  • Copolymer using nano calcium phosphate coated polymethyl methacrylate as substrate and coating method thereof

Examples

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example 1

[0034] Example 1, the synthesis of PMMA containing hydroxyl side groups is the copolymer microsphere of substrate

[0035]PMMA-based copolymer microspheres containing one or more hydroxyl side groups were synthesized by emulsion polymerization. Generally, a combination of monomers (methyl methacrylate, or other methacrylate monomers with pendant hydroxyl groups (e.g., 2-hydroxyethyl methacrylate)), distilled water, and potassium peroxodisulfate , and heated at 80 °C for 3 h in a nitrogen atmosphere. Then, the mixture was centrifuged and washed with distilled water. The PMMA-based microspheres were dried using a freeze dryer.

[0036] The types of PMMA-based microspheres synthesized are summarized in Table 1.

[0037]

[0038] PMMA-based microspheres (P, PH-1 and PH-0.5) were characterized using scanning electron microscopy (SEM). Figure 2-4 SEM images of PMMA-based microspheres are shown.

example 2

[0039] Example 2, PMMA is the nano calcium phosphate coating on the copolymer microsphere of substrate

[0040] PMMA-based microspheres (pH-0.5) and calcium hydroxide were mixed with distilled water in a beaker. Phosphoric acid was added dropwise to the reaction mixture using a syringe pump at a rate of 0.139 ml / hr. After all the phosphoric acid had been added, the reaction mixture was mixed for 1, 2 and 3 days, respectively. After complete mixing, the mixture was centrifuged and freeze-dried.

[0041] The PMMA-based copolymer microspheres coated with nano-calcium phosphate were observed by scanning electron microscopy (SEM), and the PMMA-based copolymer microspheres coated with nano-calcium phosphate were analyzed by energy dispersive X-ray (energy dispersive X-ray, EDX). ball. Nanocalcium phosphate-coated PMMA-based microspheres were immobilized on silicon wafers and coated with carbon for SEM observation. Figure 5-7 The SEM images of the reaction products after 1, 2 an...

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Abstract

The present invention relates to a copolymer using nano calcium phosphate coated polymethyl methacrylate (PMMA) as a substrate and a coating method thereof. The method comprises compounding copolymer microspheres using PMMA including a hydroxyl pendant group as a substrate, reacting calcium salt and phosphoric acid solution with the hydroxyl pendant group of the PMMA-based copolymer microspheres, and increasing the thickness of nano calcium phosphate coatings of the PMMA-based copolymer microspheres.

Description

[0001] Cross References to Related Applications [0002] The present invention claims the serial number No. US62 / 123,108, the application date is November 5, 2014, and the title is "polymethylmethacrylate (polymethylmethacrylate, PMMA)-based copolymer coated with nanometer calcium phosphate" BENEFITS AND BENEFITS OF THE US PROVISIONAL PATENT APPLICATION, WHICH IS INTRODUCED IN ITS ENTIRE THROUGH REFERENCE. technical field [0003] The present invention relates to a polymethyl methacrylate (PMMA) based copolymer with biological activity, the preparation process of the copolymer, and its use as a bioactive filler in orthopedic applications, dental applications, polymer applications and chemical applications the use of. Background technique [0004] A bone filling is a material used to fill or replace bone / teeth. The acrylic bone cement can be injected into the human body and hardened in the human body, wherein the acrylic bone cement using PMMA is a solid phase, and the acr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/06C08J3/12C08F220/14A61L27/16A61L27/12A61L27/54A61K6/083A61K6/033A61K6/838
Inventor 黃志德郭秀娟
Owner NANO & ADVANCED MATERIALS INST
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