Sodium valproate injection

A technology of sodium valproate and injection, applied in the direction of anhydride/acid/halide active ingredients, drug delivery, medical preparations of non-active ingredients, etc., can solve medical accidents, affect drug efficacy, and have no valproic acid Sodium injection and other issues
CN105326784AActive Publication Date: 2016-02-17SICHUAN CREDIT PHARMA
4 Cites 2 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SICHUAN CREDIT PHARMA
Publication Date
2016-02-17

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention provides a sodium valproate injection. The sodium valproate injection is composed of sodium valproate, a stabilizing agent, a pH regulating agent and water for injection, wherein EDTA (ethylene diamine tetraacetic acid)-2NaCa serves as the stabilizing agent. By adoption of the EDTA-2NaCa serving as the stabilizing agent, stability of the sodium valproate injection in preparation and storage is evidently superior to that of sodium valproate injections adopting other stabilizing agents, to be more specific, the sodium valproate injection in preparation and storage is small in pH value variation range, related substances are less increased, and active ingredients are less reduced. Therefore, safety of the sodium valproate injection can be further improved by adoption of the EDTA-2NaCa serving as the stabilizing agent.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a sodium valproate injection and a preparation method thereof. Background technique

[0002] The chemical name of sodium valproate is 2-sodium valproate, molecular formula: C 8 h 15 NaO 2 , with a molecular weight of 166.2, is a white, odorless, water-soluble crystalline powder with strong hygroscopicity and is suitable for various types of seizures, such as petit mal seizures, focal seizures, psychomotor seizures, mixed seizures Prevention and treatment of seizures, status epilepticus, and personality and behavioral disorders caused by epilepsy.

[0003] The mechanism of action of sodium valproate is related to the inhibition of voltage-sensitive sodium ion channels. It inhibits the metabolism of γ-aminobutyric acid, increases the accumulation of γ-aminobutyric acid in the brain, and achieves the effect of inhibiting the excessive discharge of focal neurons and the spread of abnormal discharge.

[0004] At present, sodium...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More