Method for continuously efficiently extracting parthenolide from southern magnolia leaves

A technology of parthenolide and Magnolia grandiflora is applied in the field of extracting active ingredients to achieve the effects of high content of active ingredients, reduced loss and wide sources.

Active Publication Date: 2016-02-17
长沙卫一生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a method for continuously and efficiently extracting p

Method used

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  • Method for continuously efficiently extracting parthenolide from southern magnolia leaves
  • Method for continuously efficiently extracting parthenolide from southern magnolia leaves
  • Method for continuously efficiently extracting parthenolide from southern magnolia leaves

Examples

Experimental program
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Effect test

Embodiment 1

[0042] Take 4 extraction tanks in series. Take by weighing 50kg Guangyulan fresh leaves and beating broken, leaf slurry is divided into 4 parts, each part 12.5kg, is placed in 25L volume concentration respectively in the methanol of 90%, cold immersion 20h under normal temperature, this 4 parts after cold immersion Put the leaf pulp into the four extraction tanks respectively, add 100L of methanol with a volume concentration of 90% to the first extraction tank, heat it to 65°C-70°C, keep the temperature, and extract the extract from the first extraction tank after 25 minutes. Put the liquid into the second extraction tank, heat it to 65°C-70°C, and maintain the temperature. After 25 minutes, extract the extract from the second extraction tank into the third extraction tank, heat it to 65°C-70°C, and maintain the temperature After 25 minutes, extract the extract from the third extraction tank into the fourth extraction tank, heat it to 65°C-70°C, and keep the temperature for 25...

Embodiment 2

[0046] Take 5 extraction tanks in series. Take by weighing 50kg Magnolia magnate fresh leaves and make a pulp and break it, and the leaf slurry is divided into 5 parts, each part of 10kg, and placed in 20L of ethanol with a volume concentration of 95%, cold soaking at normal temperature for 12h, and 5 parts of leaves after cold soaking Put the slurry into the five extraction tanks respectively, add 80L of ethanol with a volume concentration of 95% to the first extraction tank, heat to 65°C-70°C, keep the temperature, and extract the extract from the first extraction tank after 30 minutes into the second extraction tank, heated to 65°C-70°C, and maintained at this temperature, after 30 minutes, extract the extract from the second extraction tank into the third extraction tank, heated to 65°C-70°C, and maintained at this temperature, After 30 minutes, extract the extract from the third extraction tank into the fourth extraction tank, heat it to 65°C-70°C, and keep the temperatur...

Embodiment 3

[0050]Take 3 extraction tanks in series. Take by weighing 51kg Magnolia magnanimum fresh leaves and beating broken, leaf slurry is divided into 3 parts, each part 17kg, is placed in 34L volume concentration respectively in the amyl alcohol of 80%, cold immersion 24h under normal temperature, this 3 parts after cold immersion Put the leaf pulp into the three extraction tanks respectively, add 136L amyl alcohol with a volume concentration of 80% to the first extraction tank, heat to 65°C-70°C, keep the temperature, and extract the first extraction tank after 20min Put the extract from the second extraction tank into the second extraction tank, heat to 65°C-70°C, and keep the temperature. After 20 minutes, extract the extract from the second extraction tank into the third extraction tank, heat to 65°C-70°C, and keep The temperature is 20 minutes, the obtained extract is filtered through a three-legged centrifugal bag (200 mesh), and the filtrate is taken; then 136L of amyl alcoho...

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Abstract

A method for continuously efficiently extracting parthenolide from southern magnolia leaves comprises the steps of after crushing fresh southern magnolia leaves as a raw material, taking a polarity organic solvent as an extractant, extracting by adopting a constant temperature gradient serial extraction process, concentrating an extraction solution under reduced pressure with microwaves, and then through the simple processes of washing with water to remove impurities, decoloring, drying and the like, obtaining the parthenolide extract with the purity of 95%. Waste residue and waste liquor generated in the extraction process are subjected to the simple processes of purification, decoloring, drying and the like to make into low purity products with different parthenolide contents. Through the method, the extraction rate of the parthenolide can be furthest improved, and the prepared products with different concentrations can well adapt to different market demands. The whole extraction process is low in device requirement and high in extraction efficiency and raw material use ratio. The use level of a solvent can be reduced by 20% by the special constant temperature gradient serial extraction process, and the production cost is far lower than that of a traditional extraction process.

Description

technical field [0001] The invention relates to a method for extracting active components from plants, in particular to a method for continuously and efficiently extracting parthenolide, a unique active component, using fresh Magnolia magnificata leaves as raw materials. Background technique [0002] Magnolia is a plant of the genus Magnolia in the family Magnoliaceae. It is native to South America and distributed in North America and the south of the Yangtze River Basin in mainland China, Beijing, Lanzhou and other places. It has been grafted and cultivated by artificial introduction. Its leaves are used as medicinal parts. Headache, nasal congestion, abdominal pain, vomiting and diarrhea, high blood pressure, migraine, etc. Parthenolide is a sesquiterpene lactone compound, which has been proved to be the most active ingredient in pharmacology. Parthenolide has strong anti-tumor activity. Studies have shown that parthenolide can destroy acute myeloid leukemia cells, which ...

Claims

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Application Information

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IPC IPC(8): C07D493/04
CPCC07D493/04
Inventor 刘寒毅
Owner 长沙卫一生物科技有限公司
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