Spiro aryl phosphorus oxide or sulfide

A compound and alkyl technology, applied in the field of spirocyclic aryl phosphorus oxides or sulfides as ALK inhibitors, can solve problems such as unsatisfactory curative effect and drug loss of effectiveness
CN105330698AActive Publication Date: 2016-02-17QILU PHARMA CO LTD
9 Cites 26 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
QILU PHARMA CO LTD
Publication Date
2016-02-17

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a spiro aryl phosphorus oxide or sulfide as ALK inhibitor, and in particular discloses a compound shown in a formula (I) as an ALK inhibitor or a pharmaceutically acceptable salt thereof.
Need to check novelty before this filing date? Find Prior Art

Description

field of invention

[0001] The present invention relates to a spirocyclic aryl phosphorus oxide or sulfide as an ALK inhibitor. In particular, the present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof as ALK inhibitors. Background of the invention

[0002] Protein kinases play a dominant regulatory role in almost all types of cellular biological activities. They include proliferation, apoptosis, cytoskeletal rearrangements, differentiation, development, immune response, nervous system function and conduction. In addition, many diseases and / or disorders are associated with abnormal, abnormal or dysregulated activity of one or more kinases.

[0003] Anaplastic lymphoma kinase (ALK) is part of the receptor protein family of tyrosine kinases (RTKs). The ALK gene provides instructions for the receptor tyrosine kinase protein to transmit signals from the cell surface to the cell through a process called signal transduction. This proc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More