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Application of Micranthanone A in preparing drugs for anti-helicobacter pylori

An anti-Helicobacter pylori and Helicobacter pylori technology, applied in the directions of antibacterial drugs, pill delivery, capsule delivery, etc., can solve problems such as indigestion, destruction of flora in the digestive tract, etc., and achieve strong inhibitory activity and outstanding substantive characteristics. Effect

Inactive Publication Date: 2016-03-23
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The most important factor affecting triple therapy is considered to be the resistance of Hp to antibacterial agents; another serious problem is that proton pump inhibitors can induce indigestion, and a large amount of antibacterial agents can lead to serious destruction of the intestinal flora

Method used

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  • Application of Micranthanone A in preparing drugs for anti-helicobacter pylori
  • Application of Micranthanone A in preparing drugs for anti-helicobacter pylori

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of the compound MicranthanoneA tablet involved in the present invention:

[0016] Take 5 grams of compound Micranthanone A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0017] Embodiment 2: the preparation of the compound MicranthanoneA capsules involved in the present invention:

[0018] Take 5 grams of compound Micranthanone A, add 195 grams of starch, mix well, and pack into capsules to make 1000 capsules.

[0019] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 3

[0020] Experimental example 3: Pharmacological experiment of MicranthanoneA

[0021] 1) Tested strain: Helicobacter pylori standard strain ATCC43504 was purchased from American Type Culture Collection (ATCC). 15 clinical strains of Hp were collected from patients who received gastroscopic examination in Department of Gastroenterology, Jiangsu Provincial People's Hospital, Laboratory Department of Jiangsu Provincial Hospital of Traditional Chinese Medicine, and Gastroscopy Department of Nanjing Children's Hospital; For patients with verrucous gastritis, firstly, they were confirmed as Hp-positive by rapid urease test, and then 1-2 pieces of gastric antrum mucosa were taken, minced and inoculated with 8% horse serum, trimethoprim 1.25g / L, multi- Colistin B 2500U / L, vancomycin 10mg / L Columbia selective agar medium, cultivated at 37°C for 72 hours in a micro-aerobic environment (5% O2, 10% CO2 and 85% N2). Bacteria were collected, oxidase, catalase and urease were identified as p...

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Abstract

The invention discloses application of Micranthanone A in preparing drugs for anti-helicobacter pylori, the Micranthanone A can be used for treating diseases such as acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer and the like, and is applied to preparation of drugs for treating acute gastritis, chronic gastritis, gastric ulcer, duodenal ulcer and the like, due to the fact that a matrix type belongs to a new matrix type, and the inhibitory activity to helicobacter pylori is high, the Micranthanone A has outstanding substantive features, and obviously has remarkable improvement for prevention and treatment of helicobacter pylori infection at the same time.

Description

technical field [0001] The present invention relates to a new application of compound Micranthanone A, in particular to the application of Micranthanone A in the preparation of anti-helicobacter pylori drugs. Background technique [0002] Helicobacter pylori (Hp) is a Gram-negative spiral bacterium. Studies have shown that Helicobacter pylori is the main cause of acute and chronic gastritis and gastric and duodenal ulcers, and may be related to gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) malignant lymphoma. Recently, the World Health Organization classified Hp as a class I carcinogen, which plays a leading role in the development of gastric cancer. The current popular treatment for Hp infection is the triple therapy of taking proton pump inhibitor (PPI) plus two kinds of antibiotics (clarithromycin, amoxicillin, tetracycline, metronidazole, etc.) at the same time. The most important factor affecting triple therapy is considered to be the resistance ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P31/04
CPCA61K31/122A61K9/2059A61K9/4866
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD