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Decocting method of traditional Chinese medicine prescription

A technology for decoction and medicinal materials, which is used in pharmaceutical formulations, medical preparations containing active ingredients, plant raw materials, etc., and can solve problems such as large batch differences, unstable efficacy, and lack of optimization research on decoction and adjustment links.

Inactive Publication Date: 2016-03-30
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This recipe has been widely used in clinical practice and has good curative effect. However, at present, the decoction of "Compound Baidu Decoction" has always been done by small decoction machines, with large batch-to-batch differences and unstable drug efficacy. The optimization of the decoction and adjustment link Research is still lacking

Method used

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  • Decocting method of traditional Chinese medicine prescription
  • Decocting method of traditional Chinese medicine prescription
  • Decocting method of traditional Chinese medicine prescription

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] 1. Preparation of "Compound Baidu Decoction" samples under different decoction methods

[0046] 1. Samples with different cooking times (45min, 60min, 75min);

[0047] 2. Samples with different water additions (2cm, 3cm, 4cm and 5cm above the upper surface of the medicinal material);

[0048] 3. Cook samples in different cooking containers (casserole, iron pot);

[0049] 4. Different decoction pressures (atmospheric pressure and pressurized) decoct medicines (atmospheric pressure, 0.12MPa, 0.15MPa, 0.20MPa);

[0050] 2. Analysis of the chemical composition of samples of "Compound Baidu Decoction" by different extraction methods

[0051] Using methods such as liquid chromatography-mass spectrometry, the differences in the chemical components and chemical fingerprints of different samples of "Compound Baidu Decoction" were studied, and the effects of decoction pressure, water addition, and decoction containers on the chemical components of "Compound Baidu Decoction" wer...

Embodiment 2

[0063] The influence of embodiment 2 different decocting devices on the composition of medicine

[0064] 1 Instruments and reagents

[0065] 1.1 Instrument AcquityUPLC (American Waters company, including DAD detector, binary high-pressure gradient pump, vacuum degasser, autosampler, column thermostat, Empower2 chromatography workstation); ultrasonic cleaner (KQ-500DE, Kunshan Ultrasonic Instrument Co., Ltd.); AL204 electronic microanalytical balance (Mettler-Toledo Instrument Co., Ltd.).

[0066] 1.2 Test drug Compound Baidu Decoction (made by the 302nd Hospital of the People's Liberation Army), forsythiaside A (batch number 111810-201103), astilbin (batch number 111798-201102), forsythin (batch number 110821-201213), acetonitrile (chromatographic Pure, Fisher Company), other reagents used were analytically pure.

[0067] 2 The decoction container takes an appropriate amount of medicinal materials according to the prescription of Compound Baidu Decoction, and selects differe...

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Abstract

The invention relates to a decocting method of a traditional Chinese medicine prescription, and the traditional Chinese medicine prescription has an existing name of a compound toxin-vanquishing decoction. According to the decocting method of the traditional Chinese medicine prescription, through biological activity, therapeutic efficacy difference, chemical research and correlation analysis of different decoction methods of the compound toxin-vanquishing decoction, change rules of drug effects and chemical composition of different decoction methods are systematically investigated. Through comparison of inter-batch difference of different batches of compound toxin-vanquishing decoction decocted samples, factors causing the difference are summed up, a detection method for correlation between the traditional Chinese medicine decoction process substantial change and the therapeutic effect is established, the judging indices and standards are determined, corresponding operation regulations are established, the scientific connotation of the compound toxin-vanquishing decoction decocting process is clarified, the method for decocting the traditional Chinese medicine preparation is screened, decocting and operation specifications of the traditional Chinese medicine decoction are established, and the stability of the decocting quality of the compound toxin-vanquishing decoction is ensured through control.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a method for decocting traditional Chinese medicine prescriptions. Background technique [0002] The decoction quality of traditional Chinese medicine prescriptions is closely related to clinical practice, and quality control in the decoction process has always been an important topic in the field of Chinese medicine research. There is an ancient saying that "the method of decocting medicine should be explained in depth. The effect and ineffectiveness of the medicine are all here." The change of active ingredients in the process directly affects the quality and curative effect of the decoction. However, there is still a lack of systematic scientific research on the decoction methods of traditional Chinese medicine prescriptions, and there is a lack of scientific judgment on whether there are substantial differences between samples under different decoctio...

Claims

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Application Information

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IPC IPC(8): A61K36/90A61K36/896
Inventor 张萍马艳芹房吉祥王伽伯李春雨王国强张蓉蓉董旖王江江乔潆
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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