A flexible differential array electrochemical glucose sensor and its application method

Abstract

A flexible differential array electrochemical glucose sensor and its use method. The sensor has seven sensor units with the same structure arranged side by side, and each sensor unit has a flexible substrate and the first three-electrode monomer arranged on the flexible substrate. The structure of the first three-electrode monomer and the second three-electrode monomer is exactly the same as that of the second three-electrode monomer, and both include a reference electrode, an auxiliary electrode and a working electrode. The method of use is to use one sensor unit per day to achieve continuous measurement for 7 days, and use transposition measurement to reduce skin allergies caused by long-term extraction of interstitial fluid. The invention has the advantages of small volume and high precision, can measure in situ, realizes the integration of tissue fluid transdermal extraction and measurement of glucose concentration in the extracted tissue fluid, and solves the problem of adhesion between the sensor and the skin during the extraction process and long-term extraction Caused skin allergies and other problems, remove the influence of environmental factors on the sensor measurement results.

Description

technical field [0001] The present invention relates to a glucose sensor. In particular, it relates to an integrated flexible differential array electrochemical glucose sensor capable of realizing the transdermal extraction of interstitial fluid and measuring the glucose concentration in the extracted interstitial fluid and its use method. Background technique [0002] With the improvement of people's living standards, changes in diet structure and lifestyle, population aging and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. The importance of continuous blood glucose monitoring in the diagnosis and treatment of diabetes has been increasingly recognized by people. If painless and uninterrupted continuous blood glucose monitoring can be performed on patients and more closely data on continuous changes in blood glucose concentration can be provided, it will be able to reflect the "full picture" of the patient's blood glucose, m...

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Problems solved by technology

Although this method can also obtain the blood sugar concentration, there are many problems.

First of all, the extracted interstitial fluid exists in the form of droplets on the skin surface, which is difficult to collect. Usually, it needs to be diluted with a buffer solution, and then measured. This requires knowing the volume of the extracted interstitial fluid to be calculated. The corresponding glucose concentration increases the complexity and error of the measurement; secondly, the microfluidic chip is used to extract the tissue fluid, and the measurement needs to be completed after the liquid is transferred. During the transfer process of the liquid, some will inevitably be lost, which will cause There is a large error in the measurement result

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