A feature analysis method for RNA editing sites

A technology of RNA editing and feature analysis, applied in the field of feature analysis of RNA editing sites, can solve the problems of energy investment, lack of analysis ideas, software and hardware support, etc.
CN105528532AActive Publication Date: 2016-04-27BGI SHENZHEN CO LTD
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
BGI SHENZHEN CO LTD
Publication Date
2016-04-27

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Abstract

The invention provides a feature analysis method for RNA editing sites. The method comprises the steps of performing sequencing on to-be-analyzed samples and obtaining DNA and RNA data; analyzing the obtained data to obtain an RNA editing site data set; obtaining an RNA secondary structure free energy distribution curve of RNA editing site upstream and downstream sequences in the RNA editing site data set through statistics. The method can conveniently and rapidly analyze the basic features of RNA editing site data.
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Description

technical field

[0001] The invention belongs to the field of biotechnology, in particular, the invention relates to a method for analyzing the characteristics of RNA editing sites. Background technique

[0002] RNA editing refers to the deletion, insertion or substitution of bases that occur at the RNA level after DNA transcription and before translation. In higher organisms, the most important RNA editing is the modification of base A to I (inosine), which is usually catalyzed by ADAR proteases. Since inosine nucleotide (I) is recognized as guanine nucleotide (G) at the translational level, this editing at this site is actually an A to G switch. This change may lead to changes in the structure and function of related proteins, and may also change the structure and function of RNA that plays a regulatory role in the organism. According to relevant literature reports, the phenomenon of RNA editing is closely related to the occurrence of cancer, so it has become a new resear...

Claims

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