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Composition containing cobamamide

A technology of adenosylcobalamin and a composition is applied in the field of compositions containing adenosylcobalamin, which can solve the problems of insignificant treatment effect of megaloblastic anemia, and achieve the effect of broadening the scope of clinical application.

Inactive Publication Date: 2016-05-11
GUANGDONG YIMING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Adenosylcobalamin has a wide range of applications, safe and effective characteristics, especially for megaloblastic anemia, malnutrition anemia, anemia during pregnancy and other anemia has a strong therapeutic effect, but in the treatment of giant cells caused by folic acid deficiency The treatment effect of erythroblastic anemia is not obvious

Method used

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  • Composition containing cobamamide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The adenosylcobalamin and folic acid are mixed in a weight ratio of 3:1 to prepare a pharmaceutical composition, which is made into an oral tablet according to a conventional and common preparation method in the art.

Embodiment 2

[0017] verification:

[0018] 1. Case

[0019] Forty patients, all female, were randomly divided into treatment group (adenosylcobalamin + folic acid) and control group (adenosylcobalamin) with 20 cases each. There was no significant difference in age and condition between the two groups.

[0020] 2. Method

[0021] The treatment group orally took this Example 1 into oral tablets, 0.5 mg each time, once a day in the morning and evening.

[0022] The control group received oral adenosylcobalamin tablets, 0.5mg each time, once a day in the morning and evening.

[0023] The entire course of treatment for each patient is one month.

[0024] 3. Results

[0025]

[0026] From the data in the above table, it can be concluded that the therapeutic effect of adenosylcobalamin on megaloblastic anemia caused by folate deficiency is not obvious, while the therapeutic effect of Example 1 on megaloblastic anemia caused by folate deficiency is relatively obvious.

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Abstract

The invention discloses a composition containing cobamamide. The composition is prepared from the following ingredients in parts by weight: 3 to 9 parts of cobamamide and 1 to 2 parts of folic acid. Due to the fact that the cobamamide has an unobvious treatment effect in treating megaloblastia anemia caused by lack of the folic acid and is limited in the clinic application of treating megaloblastia anemia, through a lot of experiments, the folic acid is added in the cobamamide according to a limit ratio and is mixed with the cobamamide, a prepared medicine composition is not only used for keeping an original effect of the cobamamide for treating conventional megaloblastia anemia, but also has a very good effect for treating megaloblastia anemia caused by the lack of the folic acid, so that the clinic application range of the cobamamide is broadened.

Description

Technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a composition containing adenosylcobalamin. Background technique [0002] Adenosine cobalamin, chemical name: 5,6-dimethylbenzimidazolyl-5'-deoxyadenine nucleoside cobalamin; English name: Cobamamide. Adenosylcobalamin is mainly used for megaloblastic anemia, dystrophic anemia, anemia during pregnancy, and also for neurological diseases such as polyneuritis, radiculitis, trigeminal neuralgia, sciatica, nerve palsy, nutritional Neurological disorders and leukopenia caused by radiation and drugs. [0003] Adenosylcobalamin has a wide range of applications, is safe and effective, especially for megaloblastic anemia, malnutrition anemia, anemia during pregnancy and other anemia conditions have a strong therapeutic effect, but in the treatment of giant folate deficiency caused by The therapeutic effect of young red blood cell anemia is not obvious. Summary of the inven...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61P7/04A61K31/519
CPCA61K31/519A61K31/714A61K2300/00
Inventor 李易春
Owner GUANGDONG YIMING PHARMA
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