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Medicine composition containing carvedilol for treating hypertension and preparation method thereof

A composition and technology for hypertension, applied in the field of medicine, can solve problems such as restricting the use of carvedilol, and achieve the effects of avoiding adverse reactions of bradycardia, small side effects, and improving therapeutic effect

Inactive Publication Date: 2016-05-11
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This adverse reaction limits the clinical use of carvedolol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0040] Carvilol 10g, Poinciana 3000g, Uncaria 3000g, Guizhi 3000g, Baibu Huanyang Dan 3000g.

[0041] The preparation method of the pharmaceutical composition for treating hypertension:

[0042]a. Decoct Phoenix wood, Uncaria, Guizhi, and Baibu Huanyang Dan with water twice, add 7 volumes of water for the first time, decoct for 1.5 hours, add water 5 times the volume of the medicine for the second time, and decoct Boil for 1 hour, combine the decoction and set aside;

[0043] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0044] c. mixing carvedolol with dry medicinal powder, and granulat...

Embodiment 2

[0048] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0049] Carvilol 7.5g, Poinciana 3500g, Uncaria 2500g, Guizhi 3500g, Baibu Huanyang Dan 2500g.

[0050] The preparation method of the pharmaceutical composition for treating hypertension:

[0051] a. Decoct Phoenix wood, Uncaria, Guizhi, and Baibu Huanyang Dan with water for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, add water 6 times the volume of the medicine for the second time, and decoct Cook for 1.5 hours, combine the decoction liquid, and set aside;

[0052] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0053] c. mixing carvedolol with dry medicinal pow...

Embodiment 3

[0057] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0058] Carvilol 12.5g, Poinciana 2500g, Uncaria 3500g, Guizhi 2500g, Baibu Huanyang Dan 3500g.

[0059] The preparation method of the pharmaceutical composition for treating hypertension:

[0060] a. Decoct Phoenix wood, Uncaria, Guizhi, and Baibu Huanyang Dan with water for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add water 4 times the volume of the medicine for the second time, and decoct Boil for 0.5 hours, combine the decoction and set aside;

[0061] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0062] c. mixing carvedolol with dry medicinal powder, and...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a medicine composition containing carvedilol for treating hypertension and a preparation method thereof. The medicine composition is prepared from the following medicinal raw materials in parts by weight: 15-35 parts of carvedilol, 2000-4000 parts of royal poinciana, 2000-4000 parts of uncaria rhynchophylla, 2000-4000 parts of cassia twigs and 2000-4000 parts of neottianthe cucullat. According to the medicine composition, traditional Chinese medicinal materials and carvedilol are combined together, so that conventional adverse response of carvedilol can be avoided, and the effect for treating hypertension can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a medicinal composition containing carvedolol for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is an important etiology and risk factor of cardiovascular and cerebrovascular diseases, and 20%-30% of people worldwide suffer from hypertension. High blood pressure can affect the structure and function of the heart, brain, and kidney, and significantly increase the risk of stroke, heart failure, and end-stage renal disease. Essential hypertension accounts for 95% of the incidence of hypertension. The survey in 2002 showed that the prevalence rate of people over the age of 18 in my country was as high as 18.8%, and the number of patients reached 160 million. Therefore, the prevention and treatment of hypertension has become a major public health issue that is of the greatest concern in my country and the world. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61P9/12A61K31/403
CPCA61K9/1652A61K31/403A61K36/48A61K36/54A61K36/74A61K36/898A61K2236/331A61K2236/39A61K2236/53A61K2300/00
Inventor 不公告发明人
Owner JINAN BANGWEN MEDICAL TECH
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