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Labetalol-containing medicine composition for treating high blood pressure and preparation method thereof

A composition and high blood pressure technology, applied in the field of medicine, can solve problems such as limiting the use of labetalol, and achieve the effects of avoiding adverse reactions of bradycardia, improving therapeutic effect, and lowering blood pressure

Inactive Publication Date: 2016-05-18
JINAN BANGWEN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This adverse reaction limits the clinical use of labetalol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0039] Labetalol 100g, Li Ye 3000g, Stinky Indus 3000g, Alihong 3000g, Star Anise Lotus Leaf 3000g.

[0040] The preparation method of the pharmaceutical composition for treating hypertension:

[0041] a. Add water to decoct Liye, Stinky Indus, Alihong, and Star Anise Lotus leaves for 2 times, add 7 volumes of water for the first time, decoct for 1.5 hours, add water for 5 times the volume of the medicine for the second time, and decoct for 1 hour hours, combine the decoction and set aside;

[0042] b. Concentrate the decoction solution at 60°C and -0.06Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0043] c. mixing labetalol with dry medicina...

Embodiment 2

[0047] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0048] Labetalol 90g, Li Ye 3500g, Stinky Indus 2500g, Alihong 3500g, Star Anise Lotus Leaf 2500g.

[0049] The preparation method of the pharmaceutical composition for treating hypertension:

[0050] a. Add water to decoct Liye, Stinky Indus, Alihong and Star Anise Lotus leaves for 2 times, add 8 volumes of water for the first time, decoct for 2 hours, add 6 times the volume of medicine for the second time, decoct for 1.5 hours, combine the decoction and set aside;

[0051] b. Concentrate the decoction solution at 55°C and -0.08Mpa to a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0052] c. mixing labetalol with dry medicinal powder, and granulatin...

Embodiment 3

[0056] A pharmaceutical composition for treating hypertension, consisting of the following raw materials in proportions by weight:

[0057] Labetalol 110g, Li Ye 2500g, Stinky Indus 3500g, Alihong 2500g, Star Anise Lotus Leaf 3500g.

[0058] The preparation method of the pharmaceutical composition for treating hypertension:

[0059] a. Add water to decoct Liye, Stinky Indus, Alihong and Star Anise Lotus leaves for 2 times, add 6 volumes of water for the first time, decoct for 1 hour, add 4 times the volume of medicine for the second time, decoct for 0.5 hours, combine the decoction and set aside;

[0060] b. Concentrate the decoction liquid at 65°C and -0.04Mpa into a clear paste with a relative density of 1.08~1.12, add ethanol until the alcohol content is 75%, leave it for 12 hours, filter, and concentrate the filtrate to a relative density of 1.15~1.20 clear ointment, spray-dried to obtain dry powder;

[0061] c. mixing labetalol with dry medicinal powder, and granulatin...

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Abstract

The invention belongs to the technical field of medicine, and particularly relates to a labetalol-containing medicine composition for treating high blood pressure and a preparation method thereof. The labetalol-containing medicine composition for treating high blood pressure is prepared from, by weight, 80-120 parts labetalol, 2000-4000 parts of jasmine leaves, 2000-4000 parts of harlequin glorybower leaves and twigs, 2000-4000 parts of fomes officinalis (Vill. ex Fr.) Ames and 2000-4000 parts of leaves of common dysosma. As Chinese herbs and labetalol are combined, common adverse reactions caused by labetalol can be avoided, and the treatment effect on high blood pressure can be improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing labetalol for treating hypertension and a preparation method thereof. Background technique [0002] Hypertension is an important etiology and risk factor of cardiovascular and cerebrovascular diseases, and 20%-30% of people worldwide suffer from hypertension. High blood pressure can affect the structure and function of the heart, brain, and kidney, and significantly increase the risk of stroke, heart failure, and end-stage renal disease. Essential hypertension accounts for 95% of the incidence of hypertension. The survey in 2002 showed that the prevalence rate of people over the age of 18 in my country was as high as 18.8%, and the number of patients reached 160 million. Therefore, the prevention and treatment of hypertension has become a major public health issue that is of the greatest concern in my country and the world. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/855A61K9/16A61P9/12A61K31/609
CPCA61K36/07A61K9/1652A61K31/609A61K36/29A61K36/85A61K36/855A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 周伟
Owner JINAN BANGWEN MEDICAL TECH
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